ReviewCurrent opinion in immunology2009
Rejuvenation of the aging T cell compartment.
Review in Current opinion in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Possible Mechanisms of Lymphopenia in Severe Tuberculosis.Microorganisms · 2023Review
- The potential role of the thymus in immunotherapies for acute myeloid leukemia.Frontiers in immunology · 2023Review
- Lymphopenia and Mechanisms of T-Cell Regeneration.Cell and tissue biology · 2022Article
- A novel activity on thymocytes cells exerted by the rattlesnake (Crotalus durissus cumanensis) venom.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Hepatitis B Virus Reactivation after Receiving Cancer Chemotherapy under Administration of Leuprorelin Acetate.Internal medicine (Tokyo, Japan) · 2020Article
- Transcription-Related Dynamics from Immune Disability into Endogenous Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency.Cellular and molecular life sciences : CMLS · 2019Review
- Does patient age influence anti-cancer immunity?Seminars in immunopathology · 2019Review
- mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination.PLoS biology · 2016Article
- Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells.Immunity & ageing : I & A · 2015Article
- Aged mice repeatedly injected with plasma from young mice: a survival study.BioResearch open access · 2014Article
- Hi-TEC reprogramming for organ regeneration.Nature cell biology · 2014Article
- Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn1(-/-) mice.Cellular & molecular immunology · 2014Article
- Regeneration of the aged thymus by a single transcription factor.Development (Cambridge, England) · 2014Article
- Thymus and aging: morphological, radiological, and functional overview.Age (Dordrecht, Netherlands) · 2014Review
- Causes, consequences, and reversal of immune system aging.The Journal of clinical investigation · 2013Review
- L-Deprenyl reverses age-associated decline in splenic norepinephrine, interleukin-2 and interferon-γ production in old female F344 rats.Neuroimmunomodulation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The elderly face significant risk for susceptibility to infection and cancer because of declining immune function. Various agents used in the setting of bone marrow transplantation and aging studies represent promising approaches to combating T cell defects in the aging population. Preclinical and clinical studies on the T cell reconstitution effects of sex steroid ablation, keratinocyte growth factor, the growth hormone pathway, and the cytokines interleukin-7, interleukin-12, and interleukin-15 indicate that these strategies may be used to alleviate the effects of T cell deficiencies in the elderly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.