ReviewJournal of molecular and cellular cardiology2010
Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!
Review in Journal of molecular and cellular cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Myocardial protection by adenosine triphosphate-sensitive potassium channel opener diazoxide involves sulfonylurea receptor 2 subunit.JTCVS open · 2026Article
- Pharmacologic ROMK Inhibition Protects Against Myocardial Ischemia Reperfusion Injury.International journal of molecular sciences · 2025Article
- Dynamic duo: Kir6 and SUR in KChannels (Austin, Tex.) · 2024Review
- Kir6.1 and SUR2B in Cantú syndrome.American journal of physiology. Cell physiology · 2022Review
- Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models.Frontiers in cardiovascular medicine · 2019Review
- A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel.The Journal of general physiology · 2018Article
- Cardiac Potassium Channels: Physiological Insights for Targeted Therapy.Journal of cardiovascular pharmacology and therapeutics · 2018Review
- KATP channels in high glucose-induced rat mesangial cell proliferation and release of MMP-2 and fibronectin.Experimental and therapeutic medicine · 2017Article
- Potassium channels in the heart: structure, function and regulation.The Journal of physiology · 2017Review
- Article
- Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia.Progress in biophysics and molecular biology · 2016Article
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- Novel human ABCC9/SUR2 brain-expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging.Journal of neurochemistry · 2015Article
- Ion Channels in the Heart.Comprehensive Physiology · 2015Review
- Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries.Scientific reports · 2015Article
- Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study.The Journal of general physiology · 2014Article
- Abcc9 is required for the transition to oxidative metabolism in the newborn heart.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.Current opinion in pharmacology · 2014Review
- Multiplicity of effectors of the cardioprotective agent, diazoxide.Pharmacology & therapeutics · 2013Review
- Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethality.Journal of molecular and cellular cardiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Reconstitution of K(ATP) channel activity from coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein sub-family, has led to the elucidation of many details of channel gating and pore properties, as well as the essential roles of Kir6.2 and SUR2 subunits in generating cardiac ventricular K(ATP). However, despite this extensive body of knowledge, there remain significant holes in our understanding of the physiological role of the cardiac K(ATP) channel, and surprising new findings keep emerging. Recent findings from genetically modified animals include the apparent insensitivity of cardiac sarcolemmal channels to nucleotide levels, and unenvisioned complexities of the subunit make-up of the cardiac channels. This topical review focuses on these new findings and considers their implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.