ArticleExperimental eye research2009
Localization of complement 1 inhibitor (C1INH/SERPING1) in human eyes with age-related macular degeneration.
Article in Experimental eye research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- New Gene Targets for Diagnosis and Therapy of Diabetic Retinopathy.The Eurasian journal of medicine · 2025Article
- RNA-Seq Analysis Reveals an Essential Role of the cGMP-PKG-MAPK Pathways in Retinal Degeneration Caused by Cep250 Deficiency.International journal of molecular sciences · 2023Article
- C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration.International journal of retina and vitreous · 2022Review
- Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease.Theranostics · 2020Article
- Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration.Current stem cell reports · 2017Review
- Risk factors and biomarkers of age-related macular degeneration.Progress in retinal and eye research · 2016Review
- Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina.Human molecular genetics · 2016Article
- Association between SERPING1 rs2511989 polymorphism and age-related macular degeneration: Meta-analysis.International journal of ophthalmology · 2015Article
- Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?Journal of clinical medicine · 2014Review
- Stem cells for investigation and treatment of inherited retinal disease.Human molecular genetics · 2014Review
- Aging is not a disease: distinguishing age-related macular degeneration from aging.Progress in retinal and eye research · 2013Review
- Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-/- mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Complementing apolipoprotein secretion by cultured retinal pigment epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Complement in age-related macular degeneration: a focus on function.Eye (London, England) · 2011Review
- The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration.The British journal of ophthalmology · 2010Article
- An association study of SERPING1 gene and age-related macular degeneration in a Han Chinese population.Molecular vision · 2010Article
- Transcriptomic comparison of the retina in two mouse models of diabetes.Journal of ocular biology, diseases, and informatics · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Age-related macular degeneration (AMD) is a common degenerative disease resulting in injury to the retina, retinal pigment epithelium and choriocapillaris. Recent data from histopathology, animal models and genetic studies have implicated altered regulation of the complement system as a major factor in the incidence and progression of this disease. A variant in the gene SERPING1, which encodes C1INH, an inhibitor of the classical and lectin pathways of complement activation, was recently shown to be associated with AMD. In this study we sought to determine the localization of C1INH in human donor eyes. Immunofluorescence studies using a monoclonal antibody directed against C1INH revealed localization to photoreceptor cells, inner nuclear layer neurons, choriocapillaris, and choroidal extracellular matrix. Drusen did not exhibit labeling. Genotype at rs2511989 did not appear to affect C1INH abundance or localization, nor was it associated with significant molecular weight differences when evaluated by Western blot. In a small number of eyes (n = 7 AMD and n = 7 control) AMD affection status was correlated with increased abundance of choroidal C1INH. These results indicate that C1INH protein is present in the retina and choroid, where it may regulate complement activation.
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