ArticleNeuron2009
Shotgun proteomics in neuroscience.
Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Proteomic Analyses of the Mouse Brain.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Quantitative proteomic and phosphoproteomic analyses of the hippocampus reveal the involvement of NMDAR1 signaling in repetitive mild traumatic brain injury.Neural regeneration research · 2023Article
- Proteomic screen reveals diverse protein transport between connected neurons in the visual system.Cell reports · 2022Article
- Proteomic insights into synaptic signaling in the brain: the past, present and future.Molecular brain · 2021Review
- Advances in Proteomics Allow Insights Into Neuronal Proteomes.Frontiers in molecular neuroscience · 2021Review
- Mass synaptometry: High-dimensional multi parametric assay for single synapses.Journal of neuroscience methods · 2019Article
- Molecular basis of the functions of the mammalian neuronal growth cone revealed using new methods.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019Review
- Discovery of Novel Cell Surface Markers for Purification of Embryonic Dopamine Progenitors for Transplantation in Parkinson's Disease Animal Models.Molecular & cellular proteomics : MCP · 2018Article
- BONLAC: A combinatorial proteomic technique to measure stimulus-induced translational profiles in brain slices.Neuropharmacology · 2016Article
- Proteomic Analysis of Protein Turnover by Metabolic Whole Rodent Pulse-Chase Isotopic Labeling and Shotgun Mass Spectrometry Analysis.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Hair-bundle proteomes of avian and mammalian inner-ear utricles.Scientific data · 2015Article
- Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice.Journal of proteome research · 2015Article
- Article
- Modulation of nociceptive ion channels and receptors via protein-protein interactions: implications for pain relief.Channels (Austin, Tex.) · 2015Review
- Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis.Nature protocols · 2014Article
- Identifying protein-protein interaction in Drosophila adult heads by Tandem Affinity Purification (TAP).Journal of visualized experiments : JoVE · 2013Article
- Role of Fas-associated death domain-containing protein (FADD) phosphorylation in regulating glucose homeostasis: from proteomic discovery to physiological validation.Molecular & cellular proteomics : MCP · 2013Article
- Genomics and proteomics in solving brain complexity.Molecular bioSystems · 2013Review
- Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells.Proteome science · 2013Article
- In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mass spectrometry-based proteomics is increasingly used to address basic and clinical questions in biomedical research through studies of differential protein expression, protein-protein interactions, and posttranslational modifications. The complex structural and functional organization of the human brain warrants the application of high-throughput, systematic approaches to understand the functional alterations under normal physiological conditions and the perturbations of neurological diseases. This primer focuses on shotgun-proteomics-based tandem mass spectrometry for the identification of proteins in a complex mixture. It describes the basic concepts of protein differential expression analysis and posttranslational modification analysis and discusses several strategies to improve the coverage of the proteome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.