ArticleJournal of the International AIDS Society2009
Early initiation of antiretroviral therapy results in decreased morbidity and mortality among patients with TB and HIV.
Article in Journal of the International AIDS Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Potential of integrated national laboratory information management system in enhancing early HIV care for infants in Malawi: a report.BMJ innovations · 2026Article
- Article
- Opportunistic diseases diminish the clinical benefit of immediate antiretroviral therapy in HIV-tuberculosis co-infected adults with low CD4+ cell counts.AIDS (London, England) · 2018Article
- The impact of HIV status and antiretroviral treatment on TB treatment outcomes of new tuberculosis patients attending co-located TB and ART services in South Africa: a retrospective cohort study.BMC infectious diseases · 2015Article
- Treatment outcomes of new tuberculosis patients hospitalized in Kampala, Uganda: a prospective cohort study.PloS one · 2014Article
- Initiation of antiretroviral therapy.Indian journal of sexually transmitted diseases and AIDS · 2014Review
- Recurrent tuberculosis risk among HIV-infected adults in Tanzania with prior active tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- The effect of complete integration of HIV and TB services on time to initiation of antiretroviral therapy: a before-after study.PloS one · 2012Article
- Factors impacting early mortality in tuberculosis/HIV patients: differences between subjects naïve to and previously started on HAART.PloS one · 2012Article
- HIV & immune reconstitution inflammatory syndrome (IRIS).The Indian journal of medical research · 2011Review
- Initiating antiretrovirals during tuberculosis treatment: a drug safety review.Expert opinion on drug safety · 2011Review
- HIV and tuberculosis: a deadly human syndemic.Clinical microbiology reviews · 2011Review
- Timing of antiretroviral therapy for HIV in the setting of TB treatment.Clinical & developmental immunology · 2011Review
- Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA.The Journal of infectious diseases · 2010Article
- Management of individuals requiring antiretroviral therapy and TB treatment.Current opinion in HIV and AIDS · 2010Review
- Brief review: who 2009 guidelines for anti-retroviral theraphy: its implication for primary care physician.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2010Article
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Authors and funding
8 authors.
Funding
Abstract
introductionThe overlapping drug toxicity profiles, drug-drug interactions and complications of management of both HIV and tuberculosis (TB) in patients with advanced HIV have not been fully delineated.
methodsWe conducted a retrospective chart review of the outcomes of tuberculosis treatment among 69 HIV-infected patients with TB, who were hospitalized in Masih Daneshvari Hospital in Tehran, Iran between 2002 and 2006, and who received standard category 1 (CAT-1) regimens. Group I (N = 47) included those treated from 2002 to 2005 with highly active antiretroviral therapy (HAART) initiated after eight weeks of TB treatment for those whose CD4 count was <200 cells/mm3. Group II (N = 22) included TB patients treated from 2005 to 2006, with HAART initiated after two weeks of TB treatment if their CD4 count was <100 cells/mm3 and eight weeks after initiation of TB treatment for those whose CD4 count was between 101 and 200 cells/mm3.
resultsThere were no differences between Groups I and II with regard to: adverse drug reactions [four (8.5%) versus two (9%), p = ns]; IRIS [six (12.7%) versus three (10.7%), p = ns]; and new opportunistic infections [eight (17.0%) versus two (9.1%), p = ns]. Death, however, occurred more frequently in Group I than in Group II [13 (27.7%) versus (4.5%), p = 0.03], where HAART was initiated earlier. Injection of drugs was the most common route of HIV transmission in both groups (72.3% in Group I and 77.3% in Group II).
conclusionThis manuscript shows that in a retrospective review of HIV/TB patients hospitalized in Tehran, improved survival was associated with earlier initiation of antiretroviral therapy in HIV/TB patients with CD4 counts of below 100 cells/mm3.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.