ArticleBMC cancer2009
Low-risk susceptibility alleles in 40 human breast cancer cell lines.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Identification and functional analysis of Rattus norvegicus Mammary carcinoma susceptibility 1b (Mcs1b) nominated variants.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.Breast cancer research : BCR · 2024Article
- RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.Oncogene · 2023Article
- Elevated transcription and glycosylation of B3GNT5 promotes breast cancer aggressiveness.Journal of experimental & clinical cancer research : CR · 2022Article
- Nuclear translocation of PLSCR1 activates STAT1 signaling in basal-like breast cancer.Theranostics · 2020Article
- A CRISPR-Cas9-triggered strand displacement amplification method for ultrasensitive DNA detection.Nature communications · 2018Article
- AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program.The Journal of experimental medicine · 2017Article
- WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel.Scientific reports · 2017Article
- p62 Regulates the Proliferation of Molecular Apocrine Breast Cancer Cells.Acta histochemica et cytochemica · 2016Article
- Midostaurin preferentially attenuates proliferation of triple-negative breast cancer cell lines through inhibition of Aurora kinase family.Journal of biomedical science · 2015Article
- The CCL2 chemokine is a negative regulator of autophagy and necrosis in luminal B breast cancer cells.Breast cancer research and treatment · 2015Article
- Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity.Cell cycle (Georgetown, Tex.) · 2015Article
- C-Src-mediated RANKL-induced breast cancer cell migration by activation of the ERK and Akt pathway.Oncology letters · 2012Article
- An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.PLoS genetics · 2011Article
- [Genes beyond BRCA1 and BRCA2 for hereditary breast cancer].Wiener medizinische Wochenschrift (1946) · 2010Review
- Breast Cancer Genetic and Molecular Subtype Impacts Response to Omega-3 Fatty Acid Ethyl Esters.Nutrition and cancerArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow-risk breast cancer susceptibility alleles or SNPs confer only modest breast cancer risks ranging from just over 1.0 to 1.3 fold. Yet, they are common among most populations and therefore are involved in the development of essentially all breast cancers. The mechanism by which the low-risk SNPs confer breast cancer risks is currently unclear. The breast cancer association consortium BCAC has hypothesized that the low-risk SNPs modulate expression levels of nearby located genes.
methodsGenotypes of five low-risk SNPs were determined for 40 human breast cancer cell lines, by direct sequencing of PCR-amplified genomic templates. We have analyzed expression of the four genes that are located nearby the low-risk SNPs, by using real-time RT-PCR and Human Exon microarrays.
resultsThe SNP genotypes and additional phenotypic data on the breast cancer cell lines are presented. We did not detect any effect of the SNP genotypes on expression levels of the nearby-located genes MAP3K1, FGFR2, TNRC9 and LSP1.
conclusionThe SNP genotypes provide a base line for functional studies in a well-characterized cohort of 40 human breast cancer cell lines. Our expression analyses suggest that a putative disease mechanism through gene expression modulation is not operative in breast cancer cell lines.
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