Trial reportClinical pharmacology and therapeutics2009
Use of transdermal melatonin delivery to improve sleep maintenance during daytime.
Trial report in Clinical pharmacology and therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06910345 (Effect of Melatonin Patches on Sleep Quality in Patients Undergoing Urological Surgery), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Melatonin Patches on Sleep Quality in Patients Undergoing Urological Surgery
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature.Nutrition journal · 2014Pooled it
- The effect of preoperative melatonin patches on sleep quality in patients undergoing urological surgery.Revista da Associacao Medica Brasileira (1992) · 2026Trial
- Review
- The efficacy of transdermal melatonin in dental anxiety in children: a randomised placebo-controlled clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Melatonin promotes sleep by suppressing responses to visual stimuli via MT1 receptors.Current biology : CB · 2026Article
- Review
- Article
- Melatonin as a Chronobiotic with Sleep-promoting Properties.Current neuropharmacology · 2023Review
- Silk Fibroin Microneedle Patches for the Treatment of Insomnia.Pharmaceutics · 2021Article
- A Peptide-Functionalized Magnetic Nanoplatform-Loaded Melatonin for Targeted Amelioration of Fibrosis in Pressure Overload-Induced Cardiac Hypertrophy.International journal of nanomedicine · 2020Article
- Physiologically-based pharmacokinetic simulations in pharmacotherapy: selection of the optimal administration route for exogenous melatonin.ADMET & DMPK · 2019Article
- Evaluation of an automated pipeline for large-scale EEG spectral analysis: the National Sleep Research Resource.Sleep medicine · 2018Article
- Systemic and transdermal melatonin administration prevents neuropathology in response to perinatal asphyxia in newborn lambs.Journal of pineal research · 2018Article
- Functionalization of Cotton Fabrics with Polycaprolactone Nanoparticles for Transdermal Release of Melatonin.Journal of functional biomaterials · 2017Article
- Transdermal administration of melatonin coupled to cryopass laser treatment as noninvasive therapy for prostate cancer.Drug delivery · 2017Article
- Correlates of sleep quality in midlife and beyond: a machine learning analysis.Sleep medicine · 2017Article
- High membrane permeability for melatonin.The Journal of general physiology · 2016Article
- The impact of sleep and circadian disturbance on hormones and metabolism.International journal of endocrinology · 2015Review
- Urinary excretion of melatonin and association with breast cancer: meta-analysis and review of the literature.Breast care (Basel, Switzerland) · 2014Article
- Sex differences in circadian timing systems: implications for disease.Frontiers in neuroendocrinology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Oral melatonin (MEL) can improve daytime sleep, but the hormone's short elimination half-life limits its use as a hypnotic in shift workers and individuals with jet lag or other sleep problems. Here we show, in healthy subjects, that transdermal delivery of MEL during the daytime can elevate plasma MEL and reduce waking after sleep onset, by promoting sleep in the latter part of an 8-h sleep opportunity. Transdermal MEL may have advantages over fast-release oral MEL in improving sleep maintenance during adverse circadian phases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.