ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2009
Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- KIBRA single nucleotide polymorphism is associated with hippocampal subfield volumes and cognition across development.Brain structure & function · 2024Article
- Article
- Impaired Cognitive Flexibility and Working Memory Precedes Depression: A Rat Model to Study Depression.Neuropsychobiology · 2021Article
- KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and mild cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- The role of KIBRA in reconstructive episodic memory.Molecular medicine (Cambridge, Mass.) · 2018Article
- Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk.Schizophrenia bulletin · 2016Article
- Genetic Association Between KIBRA Polymorphism and Alzheimer's Disease with in a Japanese Population.Neuromolecular medicine · 2015Article
- Zebrafish calsyntenins mediate homophilic adhesion through their amino-terminal cadherin repeats.Neuroscience · 2015Article
- KIBRA: In the brain and beyond.Cellular signalling · 2014Article
- GABRA2 and KIBRA genotypes predict early relapse to substance use.Drug and alcohol dependence · 2012Article
- The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- Impact of common KIBRA allele on human cognitive functions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- COMT Val158Met Polymorphism Modulates Cognitive Effects of Dietary Intervention.Frontiers in aging neuroscience · 2010Article
- KIBRA: A New Gateway to Learning and Memory?Frontiers in aging neuroscience · 2010Article
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Authors and funding
5 authors.
Funding
Abstract
The kidney and brain expressed protein gene (KIBRA) and the calsyntenin 2 gene (CLSTN2) are reportedly involved in synaptic plasticity. Single nucleotide polymorphisms (SNPs) rs17070145 (KIBRA) and rs6439886 (CLSTN2) have been found to affect memory performance measures. This study examined the association of KIBRA SNP rs17070145 and CLSTN2 SNPs rs6439886 and rs17348572 (a nonsynonymous variant) with cognitive flexibility in 674 African Americans (AAs; 526 current smokers) and 419 European Americans (EAs; 318 current smokers). The subjects' cognitive flexibility was assessed using the Wisconsin Card Sorting Test. The effects on cognitive flexibility of sex, age, education, and tobacco recency (a possible mediator of gene effects in smokers), the three SNPs, and the interaction of each SNP with tobacco recency were analyzed using multivariate analysis of variance. In AAs, there were no main or interaction effects of the SNPs on cognitive flexibility. In EAs, the two CLSTN2 SNPs showed no main effect on cognitive flexibility. However, among EAs, individuals with the KIBRA rs17070145 T allele made significantly more perseverative responses (P=0.002) and perseverative errors (P=0.002) than those with no T allele. Furthermore, among EAs with the rs17070145 T allele, current smokers made significantly fewer perseverative responses (P<0.001) and perseverative errors (P<0.001) than past smokers. Nongenetic factors (age, education, and tobacco recency) had substantial effects on cognitive flexibility in both AAs and EAs. We conclude that variation in KIBRA influences cognitive flexibility in a population-specific way, and that current smoking status moderates this effect.
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