ReviewJournal of leukocyte biology2009
Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages.
Review in Journal of leukocyte biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed.
- Trial
- Review
- Characterisation of human in vitro tumour-associated macrophage models to define translational relevance.Scientific reports · 2025Article
- Mesangiogenic progenitor cells: a mesengenic and vasculogenic branch of hemopoiesis? A story of neglected plasticity.Frontiers in cell and developmental biology · 2025Article
- ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype.The Journal of experimental medicine · 2024Article
- Methylome-wide analysis in systemic microbial-induced experimental periodontal disease in mice with different susceptibility.Frontiers in cellular and infection microbiology · 2024Article
- Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology.Pharmaceutics · 2023Review
- Promoting Angiogenesis Using Immune Cells for Tissue-Engineered Vascular Grafts.Annals of biomedical engineering · 2023Review
- Nanotopographical cues for regulation of macrophages and osteoclasts: emerging opportunities for osseointegration.Journal of nanobiotechnology · 2022Review
- Effects of macrophage polarization on gold nanoparticle-assisted plasmonic photothermal therapy.RSC advances · 2021Article
- Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Immunomodulation for maxillofacial reconstructive surgery.Maxillofacial plastic and reconstructive surgery · 2020Review
- M2-Like Tumor-Associated Macrophage-Targeted Codelivery of STAT6 Inhibitor and IKKβ siRNA Induces M2-to-M1 Repolarization for Cancer Immunotherapy with Low Immune Side Effects.ACS central science · 2020Article
- Fetal exposure to oncoantigen elicited antigen-specific adaptive immunity against tumorigenesis.Journal for immunotherapy of cancer · 2020Article
- Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration.International journal of biological sciences · 2020Article
- Chronic Hepatitis C Virus Infection Impairs M1 Macrophage Differentiation and Contributes to CD8Cells · 2019Article
- Trained Innate Immunity and Its Implications for Mucosal Immunity and Inflammation.Advances in experimental medicine and biology · 2019Review
- Semaphorin 7A Promotes Macrophage-Mediated Lymphatic Remodeling during Postpartum Mammary Gland Involution and in Breast Cancer.Cancer research · 2018Article
- Targeting Macrophages as a Potential Therapeutic Intervention: Impact on Inflammatory Diseases and Cancer.International journal of molecular sciences · 2018Review
- Macrophage Populations in Visceral Adipose Tissue from Pregnant Women: Potential Role of Obesity in Maternal Inflammation.International journal of molecular sciences · 2018Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The extent to which the functional heterogeneity of Mvarphis is dependent on the differentiation of functional sublineages remains unresolved. One alternative hypothesis proposes that Mvarphis are functionally plastic cells, which are capable of altering their functional activities progressively in response to progressively changing signaling molecules generated in their microenvironment. This "functional plasticity" hypothesis predicts that the functionally polarized Mvarphis in chronic pathologies do not represent Mvarphi sublineages but rather, are mutable phenotypes sustained by chronic signaling from the pathological environment. Solid TAMvarphis are chronically polarized to provide activities that support tumor growth and metastasis and suppress adaptive immune responses. In support of the functional plasticity hypothesis, administration of slow-release microsphere-encapsulated IL-12 successfully reprogrammed TAMvarphis in situ, reducing Mvarphi support of tumor growth and metastasis and enhancing Mvarphi proimmunogenic activities. Increased knowledge of how Mvarphi function is regulated and how polarized Mvarphis can be reprogrammed in situ will increase our ability to control Mvarphi function in a variety of pathological states, including cancer and chronic inflammatory disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.