ArticleThe American journal of psychiatry2009
Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children.
Article in The American journal of psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins.European journal of nutrition · 2012Trial
- Catechol-O-methyltransferase gene (COMT) is associated with neurocognitive functioning in patients with sickle cell disease.Current research in translational medicine · 2024Article
- Impact of cognition-related single nucleotide polymorphisms on brain imaging phenotype in Parkinson's disease.Neural regeneration research · 2023Article
- Schoolchildren's autobiographical memory: COMT gene ValCognitive processing · 2022Article
- Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex.Experimental brain research · 2020Article
- Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View.Frontiers in pediatrics · 2020Article
- Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study.Journal of affective disorders · 2018Article
- Influence of Dopamine-Related Genes on Neurobehavioral Recovery after Traumatic Brain Injury during Early Childhood.Journal of neurotrauma · 2017Article
- Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD.PloS one · 2017Article
- Catechol-O-methyltransferase Val158met polymorphism interacts with early experience to predict executive functions in early childhood.Developmental psychobiology · 2015Article
- Using cross-species comparisons and a neurobiological framework to understand early social deprivation effects on behavioral development.Development and psychopathology · 2015Review
- A neurogenetics approach to defining differential susceptibility to institutional care.International journal of behavioral development · 2015Article
- The effects of life stress and neural learning signals on fluid intelligence.European archives of psychiatry and clinical neuroscience · 2015Article
- Sex differences in COMT polymorphism effects on prefrontal inhibitory control in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Genetic polymorphisms affecting susceptibility to mercury neurotoxicity in children: summary findings from the Casa Pia Children's Amalgam clinical trial.Neurotoxicology · 2014Article
- Contributions of COMT Val¹⁵⁸ Met to cognitive stability and flexibility in infancy.Developmental science · 2014Article
- Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.Neuromolecular medicine · 2014Observational
- Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission.Frontiers in behavioral neuroscience · 2014Review
- Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children.Journal of toxicology and environmental health. Part A · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveGenetic variants that contribute to the risk of psychiatric disorders may also affect normal variation in psychological function. Indeed, the behavioral effects of many genetic variants may be better understood as process-specific rather than disease-specific. A functional valine-to-methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with cognitive function and brain metabolic activity accompanying such tasks. Not all studies are consistent, and less is known about the effect of this polymorphism during development. The authors tested the hypothesis that a more informative COMT haplotype predicts normal cognitive development in a large population-based cohort of children enrolled in the Avon Longitudinal Study of Parents and Children.
methodEffects on verbal and performance IQ as well as verbal inhibition were assessed at age 8, and effects on working memory were assessed at age 10. From the five COMT single nucleotide polymorphisms (SNPs) genotyped, the effect of a functional three-SNP haplotype consisting of Val(158)Met and two synonymous SNPs (rs6269 and rs4818), which together exert a major influence on the level of COMT expression and enzyme activity, was evaluated.
resultsThis three-SNP haplotype predicted both verbal inhibition and working memory, and there was a genotype-by-sex interaction on verbal IQ. The effect of COMT genotype (diplotype) on cognition was curvilinear, which is consistent with the "inverted U" model of dopamine effect on frontal cortical efficiency. In addition, the SNP rs2075507 (previously rs2097603) was independently associated with verbal inhibition, while rs165599 showed no main cognitive effects. However, rs165599 showed a genotype-by-sex interaction with working memory.
conclusionsGenetic variation at several loci in the COMT gene affects normal cognitive function in children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.