ArticleThe Kaohsiung journal of medical sciences2009
Vardenafil reduces testicular damage following ischemia/reperfusion injury in rats.
Article in The Kaohsiung journal of medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Vardenafil Alleviates Doxorubicin-Induced Cardiotoxicity Associated with Restoration of the AMPK/SIRT1 Signaling Pathway.Biomedicines · 2026Article
- Potential therapeutic targets in the prevention of testicular ischemia-reperfusion injury.Frontiers in reproductive health · 2025Review
- Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models.Heliyon · 2024Review
- Anti-inflammatory and anti-oxidant action of tadalafil in testicular regeneration process after heat stress.Animal reproduction · 2024Article
- Protective and therapeutic effects of sildenafil and tadalafil on aflatoxin B1-induced hepatocellular carcinoma.Molecular and cellular biochemistry · 2021Article
- Testicular Torsion and Spermatogenesis.Advances in experimental medicine and biology · 2021Article
- Protective Effect of Udenafil Against Ischemia Reperfusion Injury Due to Testicular Torsion/Detorsion in Rat Model.The Eurasian journal of medicine · 2020Article
- Protective effect of dipeptidyl peptidase-4 inhibitors in testicular torsion/detorsion in rats: a possible role of HIF-1α and nitric oxide.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Erythropoietin and sildenafil protect against ischemia/reperfusion injury following testicular torsion in adult rats.Experimental and therapeutic medicine · 2017Article
- Ginkgo Biloba Ameliorates Subfertility Induced by Testicular Ischemia/Reperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism.Oxidative medicine and cellular longevity · 2016Article
- The protective effects of tadalafil on renal damage following ischemia reperfusion injury in rats.The Kaohsiung journal of medical sciences · 2015Article
- Mechanisms of testicular torsion and potential protective agents.Nature reviews. Urology · 2014Review
- Comparison of erythropoietin and sildenafil protective role against ischemia/reperfusion injury of the testis in adult rats.International urology and nephrology · 2014Article
- Contemporary review of testicular torsion: new concepts, emerging technologies and potential therapeutics.Journal of pediatric urology · 2013Review
- PDE5 inhibition against acute renal ischemia reperfusion injury in rats: does vardenafil offer protection?World journal of urology · 2013Article
- Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion.Clinics (Sao Paulo, Brazil) · 2011Article
- The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats.Asian journal of andrologyArticle
- The protective effect of L-arginine, tadalafil, and their combination in rat testes after ischemia and reperfusion injury.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
- The biochemical effects of ischemia-reperfusion injury in the ipsilateral and contralateral testes of rats and the protective role of melatonin.Asian journal of andrologyArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effect of intraperitoneal vardenafil (1 mg/kg) administration during an ischemic period in a rat model of testicular torsion/detorsion (T/D). Twenty-one adult Wistar rats were equally randomized into a control group, a T/D group and a vardenafil group. The control group was designed to collect basal values for biochemical and histopathological parameters. The T/D group underwent testicular torsion for 1 hour. The vardenafil group received vardenafil (1 mg/kg) intraperitoneally at 30 minutes after torsion. All rats were sacrificed 4 hours after reperfusion to evaluate the tissue levels of malondialdehyde and total antioxidant status. Germ cell apoptosis was evaluated using the apoptosis protease activating factor 1 antibody in all groups. The expressions of endothelial nitric oxide synthase (NOS) and inducible NOS were also assessed in both testes of all rats. The malondialdehyde levels in the T/D group were significantly higher than in the control and vardenafil groups. There were also significant decreases in total antioxidant status in the T/D group compared with the control and vardenafil groups. Vardenafil treatment significantly reduced apoptosis protease activating factor 1, endothelial NOS and inducible NOS levels in the vardenafil group compared with the T/D group. Administration of 1 mg/kg vardenafil during testicular torsion decreased ischemia/reperfusion cellular damage. Our results indicate that the reduction in oxidative stress by vardenafil may play a major role in its cytoprotective effects.
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