ArticleBMC neuroscience2009
Estrous cycle influences the expression of neuronal nitric oxide synthase in the hypothalamus and limbic system of female mice.
Article in BMC neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- Ventromedial hypothalamus (VMHvl) nNOS neurons regulate social behaviors in a sex-specific manner.Communications biology · 2025Article
- Nitric Oxide Regulates Estrus Cycle Dependent Colonic Motility in Mice.Frontiers in neuroscience · 2021Article
- Integrative Analysis of Vaginal Microorganisms and Serum Metabolomics in Rats With Estrous Cycle Disorder Induced by Long-Term Heat Exposure Based on 16S rDNA Gene Sequencing and LC/MS-Based Metabolomics.Frontiers in cellular and infection microbiology · 2021Article
- Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia.Scientific reports · 2020Article
- Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?Endocrine · 2018Review
- Phenotyping of nNOS neurons in the postnatal and adult female mouse hypothalamus.The Journal of comparative neurology · 2017Article
- Role of neuronal nitric oxide synthase in the estrogenic attenuation of cannabinoid-induced changes in energy homeostasis.Journal of neurophysiology · 2015Article
- Estrous cycle and sex affect cocaine-induced behavioural changes in CD1 mice.Psychopharmacology · 2014Article
- Sex-specific differences in natriuretic peptide and nitric oxide synthase expression in ANP gene-disrupted mice.Molecular and cellular biochemistry · 2013Article
- Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Of mice and rats: key species variations in the sexual differentiation of brain and behavior.Frontiers in neuroendocrinology · 2010Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNitric oxide plays an important role in the regulation of male and female sexual behavior in rodents, and the expression of the nitric oxide synthase (NOS) is influenced by testosterone in the male rat, and by estrogens in the female. We have here quantitatively investigated the distribution of nNOS immunoreactive (ir) neurons in the limbic hypothalamic region of intact female mice sacrificed during different phases of estrous cycle.
resultsChanges were observed in the medial preoptic area (MPA) (significantly higher number in estrus) and in the arcuate nucleus (Arc) (significantly higher number in proestrus). In the ventrolateral part of the ventromedial nucleus (VMHvl) and in the bed nucleus of the stria terminalis (BST) no significant changes have been observed. In addition, by comparing males and females, we observed a stable sex dimorphism (males have a higher number of nNOS-ir cells in comparison to almost all the different phases of the estrous cycle) in the VMHvl and in the BST (when considering only the less intensely stained elements). In the MPA and in the Arc sex differences were detected only comparing some phases of the cycle.
conclusionThese data demonstrate that, in mice, the expression of nNOS in some hypothalamic regions involved in the control of reproduction and characterized by a large number of estrogen receptors is under the control of gonadal hormones and may vary according to the rapid variations of hormonal levels that take place during the estrous cycle.
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