ArticleThe Journal of infectious diseases2009
A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 86 citations in OpenAlex.
- Case Report: Fulminant shock due to PVL-positiveFrontiers in medicine · 2026Article
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- Clinical and microbiological characteristics of persistent Staphylococcus aureus bacteremia, risk factors for mortality, and the role of CD4Scientific reports · 2024Article
- The Epistemology of Bacterial Virulence Factor Characterization.Microorganisms · 2024Review
- The role of Staphylococcus aureus quorum sensing in cutaneous and systemic infections.Inflammation and regeneration · 2024Review
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Pathogenicity and virulence ofVirulence · 2021Review
- Review
- Role of Phenol-Soluble Modulins in Staphylococcus epidermidis Biofilm Formation and Infection of Indwelling Medical Devices.Journal of molecular biology · 2019Article
- Article
- A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues.Journal of visualized experiments : JoVE · 2019Article
- Article
- Aspartic Acid Residue 51 of SaeR Is Essential forFrontiers in microbiology · 2018Article
- Humanized Mice Exhibit Increased Susceptibility to Staphylococcus aureus Pneumonia.The Journal of infectious diseases · 2017Article
- Humanized Mouse Models ofFrontiers in immunology · 2017Review
- Article
- Inflammasome Activation Can Mediate Tissue-Specific Pathogenesis or Protection in Staphylococcus aureus Infection.Current topics in microbiology and immunology · 2016Review
- Innate Immune Signaling Activated by MDR Bacteria in the Airway.Physiological reviews · 2016Review
- Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.Scientific reports · 2015Article
- Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
sThe role of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S. aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by earlier investigators. In agreement with other studies that failed to detect similar effects of PVL using community-associated methicillin-resistant S. aureus strains, we found no significant effect of PVL on gene expression or pathogenesis after we repaired the mutation. These findings provide further evidence that PVL does not have a major impact on S. aureus pathogenesis. Moreover, our results demonstrate that a single nucleotide polymorphism in an intergenic region can dramatically affect bacterial physiology and virulence. Finally, our work emphasizes the need to frequently evaluate the integrity of the S. aureus agr locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.