ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2010
Primary cilia are highly oriented with respect to collagen direction and long axis of extensor tendon.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- The Primary Cilium: A New Player in Muscle Stem Cell Biology.Stem cell reviews and reports · 2026Review
- The factory, the antenna and the scaffold: the three-way interplay between the Golgi, cilium and extracellular matrix underlying tissue function.Biology open · 2023Review
- Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism.Frontiers in dental medicine · 2023Article
- Current Concepts and Methods in Tissue Interface Scaffold Fabrication.Biomimetics (Basel, Switzerland) · 2022Review
- Role of Primary Cilia in Skeletal Disorders.Stem cells international · 2022Review
- Ultrastructural evidence for telocytes in equine tendon.Journal of anatomy · 2021Article
- Electrospun Fiber Alignment Guides Osteogenesis and Matrix Organization Differentially in Two Different Osteogenic Cell Types.Frontiers in bioengineering and biotechnology · 2021Article
- The Primary Cilium on Cells of Developing Skeletal Rudiments; Distribution, Characteristics and Response to Mechanical Stimulation.Frontiers in cell and developmental biology · 2021Article
- Physiological and Pathophysiological Aspects of Primary Cilia-A Literature Review with View on Functional and Structural Relationships in Cartilage.International journal of molecular sciences · 2020Review
- Review
- Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6.Scientific reports · 2018Article
- Mechanobiology of limb musculoskeletal development.Annals of the New York Academy of Sciences · 2017Review
- Primary cilia: Cell and molecular mechanosensors directing whole tissue function.Seminars in cell & developmental biology · 2017Review
- Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Microarray profiling analysis of long non-coding RNAs expression in tendinopathy: identification for potential biomarkers and mechanisms.International journal of experimental pathology · 2015Article
- Tendon mechanobiology: Current knowledge and future research opportunities.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Review
- Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- The pain of tendinopathy: physiological or pathophysiological?Sports medicine (Auckland, N.Z.) · 2014Review
- Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.Scientific reports · 2013Article
- Tendon cell ciliary length as a biomarker of in situ cytoskeletal tensional homeostasis.Muscles, ligaments and tendons journal · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Skeletal tissues adapt to their mechanical environments by modulating gene expression, cell metabolism, and extracellular matrix (ECM) architecture; however, the mechanosensory mechanisms for these processes are incompletely understood. Primary cilia have emerged as critical components of the cellular mechanosensory apparatus and have been hypothesized to participate in establishment of cellular and ECM orientation, but their function in skeletal tissues is just beginning to be examined. Here we focused on tendon, a tissue with an oriented matrix that is ideal for analysis of spatial relationships between primary cilia and the ECM. The objective of this study was to characterize the incidence and orientation of tenocyte primary cilia in their native ECM. Primary cilia, nuclei, and collagen were analyzed three-dimensionally in immunofluorescently labeled rat extensor tendon using multiphoton microscopy and semiautomated morphometry. Primary cilia were observed in 64% of tenocytes. The cilia were highly oriented with respect to the ECM: cilia were aligned parallel to the collagen fibers and the long axis of the tendon. This study represents the first quantification of the in situ incidence and orientation of primary cilia in tendon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.