ArticlePediatric nephrology (Berlin, Germany)2010
Limitations of dual x-ray absorptiometry in children with chronic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Teenagers and young adults with nephropathic cystinosis display significant bone disease and cortical impairment.Pediatric nephrology (Berlin, Germany) · 2018Trial
- Article
- The assessment and treatment of the musculoskeletal manifestations of cystinosis.Frontiers in nephrology · 2025Review
- Mineral bone disorder in children with chronic kidney disease: Data from the KNOW-Ped CKD (Korean cohort study for outcome in patients with pediatric chronic kidney disease) study.Frontiers in pediatrics · 2023Article
- Pediatric CKD-MBD: existing and emerging treatment approaches.Pediatric nephrology (Berlin, Germany) · 2022Article
- Association between insulin growth factor-1, bone mineral density, and frailty phenotype in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- A prospective case-control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT.Scientific reports · 2021Article
- Management of bone disease in cystinosis: Statement from an international conference.Journal of inherited metabolic disease · 2019Article
- Skeletal status assessment by quantitative ultrasound and bone densitometry in children with different renal conditions.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Nephropathic Cystinosis: Symptoms, Treatment, and Perspectives of a Systemic Disease.Frontiers in pediatrics · 2018Article
- Treatment of Pediatric Chronic Kidney Disease-Mineral and Bone Disorder.Current osteoporosis reports · 2017Review
- Prevalence of vitamin D insufficiency among adolescents and its correlation with bone parameters using high-resolution peripheral quantitative computed tomography.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Longitudinal assessment of bone quality in pediatric patients with chronic kidney disease in relation to treatment modality.Journal of bone and mineral metabolism · 2015Article
- Reference values of bone stiffness index and C-terminal telopeptide in healthy European children.International journal of obesity (2005) · 2014Article
- Skeletal effects and growth in children with chronic kidney disease: a 5-year prospective study.Journal of bone and mineral metabolism · 2013Article
- Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography.Pediatric rheumatology online journal · 2013Article
- The consequences of chronic kidney disease on bone metabolism and growth in children.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Review
- Can bisphosphonates play a role in the treatment of children with chronic kidney disease?Pediatric nephrology (Berlin, Germany) · 2011Review
- CKD-MBD after kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2011Review
- Mineral and bone disorders in children with chronic kidney disease.Nature reviews. Nephrology · 2011Review
Corrections and comments
- Comment on
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dual x-ray absorptiometry (DXA) is the most widely used densitometric method for diagnosing osteoporosis in adults. It has also been widely adopted as a diagnostic tool in the pediatric population. The most significant limitation of DXA is its reliance on areal rather than volumetric bone mineral density (BMD), which results in an artificial underestimation of bone density in short people. Poor longitudinal growth, however, is an eminent problem in children with chronic kidney disease (CKD). There is also no evidence in children that areal BMD is predictive of future fracture risk, which is the traditional rationale for measuring BMD in children with CKD. Therefore, the Kidney Disease Outcomes Quality Initiative guidelines and the current position of the International Society for Clinical Densitometry (ISCD) on pediatric patients, both of which are presented in this issue of Pediatric Nephrology, do not recommend the use of DXA in children with CKD. To date, there is no consensus on the best method to assess the degree of renal osteodystrophy in this patient population, and further collaborative efforts to correlate densitometric findings with clinical outcomes are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.