ArticleClinical research in cardiology : official journal of the German Cardiac Society2009
Renal dysfunction is associated with shorter telomere length in heart failure.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Shorter kidney telomeres are associated with nephrosclerosis by an epigenetic signature.Cardiovascular research · 2026Article
- Article
- Review
- Telomere Attrition in Chronic Kidney Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Association Between Baseline Buccal Telomere Length and Progression of Kidney Function: The Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Roles of telomeres and telomerase in age‑related renal diseases (Review).Molecular medicine reports · 2021Review
- Study of Cellular Aging in a Cohort of Patients with Heart Failure.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2021Article
- How metabolic acidosis and kidney disease may accelerate the aging process.European journal of clinical nutrition · 2020Review
- Short Leukocyte Telomere Length Predicts Albuminuria Progression in Individuals With Type 2 Diabetes.Kidney international reports · 2018Article
- Telomere attrition in heart failure: a flow-FISH longitudinal analysis of circulating monocytes.Journal of translational medicine · 2018Article
- Peripheral Blood Leukocyte Telomere Length Is Associated with Age but Not Renal Function: A Cross-Sectional Follow-Up Study.The journal of nutrition, health & aging · 2018Article
- Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States.Oncotarget · 2017Article
- Short telomere length is associated with renal impairment in Japanese subjects with cardiovascular risk.PloS one · 2017Article
- Impact of Oxidative Stress in Premature Aging and Iron Overload in Hemodialysis Patients.Oxidative medicine and cellular longevity · 2016Article
- Association of relative telomere length with progression of chronic kidney disease in two cohorts: effect modification by smoking and diabetes.Scientific reports · 2015Article
- Genomic Integrity Is Favourably Affected by High-Intensity Interval Training in an Animal Model of Early-Stage Chronic Kidney Disease.Sports medicine - open · 2015Article
- Assessment of serum cotinine in patients with chronic heart failure: self-reported versus objective smoking behaviour.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Association between kidney function and telomere length: the heart and soul study.American journal of nephrology · 2012Article
- Aging, telomeres and heart failure.Heart failure reviews · 2010Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal dysfunction is a frequent comorbidity associated with high mortality in patients with chronic heart failure (CHF). The intrinsic biological age might affect the ability of the kidney to cope with the challenging environment caused by CHF. We explored the association between leukocyte telomere length, a marker for biological age, and renal function in patients with CHF. METHODS AND
resultsTelomere length was determined by a real-time quantitative polymerase chain reaction in 866 CHF patients. Renal function was estimated with the simplified Modification of Diet in Renal Disease equation. The median age was 74 (interquartile range 64-79) years, 61% male, left ventricular ejection fraction of 30 (23-44)%, and the estimated glomerular filtration rate was 53 (40-68) ml/min/1.73 m(2). Telomere length was associated with renal function (correlation coefficient 0.123, P < 0.001). This relationship remained significant after adjustment for age, gender, age of CHF onset (standardized-beta 0.091, P = 0.007). Also additionally adjusting for the severity of CHF and baseline differences did not change our findings.
conclusionThe association between shorter leukocyte telomere length and reduced renal function in heart failure suggests that intrinsic biological aging affects the ability of the kidney to cope with the systemic changes evoked by heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.