ReviewMolecular medicine (Cambridge, Mass.)
The hepatic response to thermal injury: is the liver important for postburn outcomes?
Review in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06899958 (Metabolism Enhancement by Laser Therapy), which is not on this map. Cited by 88 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolism Enhancement by Laser Therapy
Who cites it
88 citing papers in PubMed, 170 citations in OpenAlex.
- Occurrence of multiorgan dysfunction in pediatric burn patients: incidence and clinical outcome.Annals of surgery · 2014Trial
- Evolving Burn Care: The Transition from Life Preservation to Life Restoration-A Narrative Review.Journal of clinical medicine · 2026Review
- Characterisation and Prognostic Implication of Cholestasis After Burn Injury.Alimentary pharmacology & therapeutics · 2026Article
- Detection of Liver Dysfunction in Severe Burn Injury with Bedside Measurement of Perfusion.Medicina (Kaunas, Lithuania) · 2026Observational
- A Microfibrous Extracellular Matrix Platform forACS pharmacology & translational science · 2026Article
- Bone marrow-derived mesenchymal stem cells alleviate hepatic lipid metabolism disorders after scald injury: integrating liver transcriptome and metabolome.Stem cell research & therapy · 2026Article
- Hypermetabolism and Lipid Alterations Postburn: A Cardiovascular Perspective.Cardiovascular therapeutics · 2026Review
- Burns: The "Fuse" That Ignites Organ Crisis - A Narrative Review of Mechanisms and Crosstalk in Post-Burn MODS.Journal of inflammation research · 2026Review
- Cytokine Storm in a Massively Burned Pediatric Patient.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Metabolic and Hormonal Changes in Pediatric Burn Patients: Mechanisms, Evidence, and Care Strategies.European burn journal · 2025Review
- Article
- Study on metabolic disorders in rat liver induced by different times after scalds.Biochemistry and biophysics reports · 2025Article
- Burn-induced mitochondrial dysfunction in hepatocytes: The role of methylation-controlled J protein silencing.The journal of trauma and acute care surgery · 2025Article
- Association Between Chromium and Lead Exposure and Liver Injury Biomarkers Among Adults in Addis Ababa, Ethiopia.Environmental health insights · 2025Article
- Delayed hepatic response and impaired cytokine dynamics in aged mice following burn injury: Implications for elderly patient care.PloS one · 2025Article
- Protective effects of insulin treatment in the morphological alterations and oxidative damage to DNA in the liver of young rats subjected to skin scald burn injury.International journal of burns and trauma · 2025Article
- Decoding burn trauma: biomarkers for early diagnosis of burn-induced pathologies.Biomarker research · 2024Review
- Pathophysiology of Severe Burn Injuries: New Therapeutic Opportunities From a Systems Perspective.Journal of burn care & research : official publication of the American Burn Association · 2024Review
- Update on Hypermetabolism in Pediatric Burn Patients.Seminars in plastic surgery · 2024Review
- [Multicenter retrospect analysis of early clinical features and analysis of risk factors on prognosis of elderly patients with severe burns].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Thermal injury produces a profound hypermetabolic and hypercatabolic stress response characterized by increased endogenous glucose production via gluconeogenesis and glycogenolysis, lipolysis, and proteolysis. The liver is the central body organ involved in these metabolic responses. It is suggested that the liver, with its metabolic, inflammatory, immune, and acute phase functions, plays a pivotal role in patient survival and recovery by modulating multiple pathways following thermal injury. Studies have evaluated the role and function of the liver during the postburn response and showed that liver integrity and function are essential for survival, and that hepatic acute phase proteins are strong predictors for postburn survival. This review discusses these studies and delineates the pivotal role of the liver in patients following severe thermal injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.