Trial reportAnesthesiology2009
Lumbar sympathetic blockade in children with complex regional pain syndromes: a double blind placebo-controlled crossover trial.
Trial report in Anesthesiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Local anaesthetic sympathetic blockade for complex regional pain syndrome.The Cochrane database of systematic reviews · 2016Pooled it
- Effect of Spinal Cord Stimulation on Skin Temperature in Patients with Neuropathic Pain: An Observational Study.Journal of pain research · 2025Article
- Effectiveness of Ultrasound-Guided Stellate Ganglion Block in Treating Pediatric Complex Regional Pain Syndrome.Cureus · 2025Article
- Interventional pain management of CRPS in the pediatric population: A literature review.Interventional pain medicine · 2024Review
- Lumbar Sympathetic Block to Treat CRPS in an 18-Month-Old Girl: A Breaking Barriers Case Report and Review of Literature.Pain and therapy · 2024Review
- Retrospective Evaluation of the Effect of Lumbar Sympathetic Blockade on Pain Scores, Fontaine Classification, and Collateral Perfusion Status in Patients with Lower Extremity Peripheral Arterial Disease.Medicina (Kaunas, Lithuania) · 2024Article
- Application of PainDETECT in pediatric chronic pain: how well does it identify neuropathic pain and its characteristics?Pain reports · 2023Article
- Pain-Related Stigma and Its Associations With Clinical and Experimental Pain Severity in Youth With Chronic Musculoskeletal Pain Conditions.Journal of pediatric psychology · 2023Article
- Signs and symptoms of pediatric complex regional pain syndrome - type 1: A retrospective cohort study.Canadian journal of pain = Revue canadienne de la douleur · 2023Article
- Modified Sensory Testing in Non-verbal Patients Receiving Novel Intrathecal Therapies for Neurological Disorders.Frontiers in neurology · 2022Article
- Quantitative Analysis of Real-Time Infrared Thermography for the Assessment of Lumbar Sympathetic Blocks: A Preliminary Study.Sensors (Basel, Switzerland) · 2021Article
- Article
- An Integrative Neuroscience Framework for the Treatment of Chronic Pain: From Cellular Alterations to Behavior.Frontiers in integrative neuroscience · 2018Article
- Short- and long-term results of an inpatient programme to manage Complex Regional Pain Syndrome in children and adolescents.British journal of pain · 2017Article
- Ganglion blocks as a treatment of pain: current perspectives.Journal of pain research · 2017Review
- [Please don't hurt me!: a plea against invasive procedures in children and adolescents with complex regional pain syndrome (CRPS)].Schmerz (Berlin, Germany) · 2012Article
- Testing the link between sympathetic efferent and sensory afferent fibers in neuropathic pain.Anesthesiology · 2012Article
- Evidence based guidelines for complex regional pain syndrome type 1.BMC neurology · 2010Article
- Neuropathic pain in children: Special considerations.Mayo Clinic proceedings · 2010Review
- Complex regional pain syndrome in children: asking the right questions.Pain research & managementReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSympathetic blockade is used in the management of complex regional pain syndromes in children, but there are no data on the efficacy or mechanism(s) by which it produces pain relief. The purpose of this study is to compare the efficacy of lidocaine administered by lumbar sympathetic to IV route.
methodsUnder general anesthesia, children with unilateral lower limb complex regional pain syndromes received catheters along the lumbar sympathetic chain. In a double-blind placebo-controlled crossover design, patients received IV lidocaine and lumbar sympathetic saline or lumbar sympathetic lidocaine and IV saline. Spontaneous and evoked pain ratings and sensory thresholds were assessed before and after these two lidocaine/saline doses and between routes of lumbar sympathetic blockade and IV.
resultsTwenty-three patients, ages 10-18 yr, were enrolled. There was evidence for reduction of mean pain intensity of allodynia to brush (mean -1.4, 95% confidence interval [CI] -2.5 to -0.3) and to pinprick temporal summation (mean -1.3, 95% CI -2.5 to -0.2) with lidocaine treatment via the lumbar sympathetic blockade compared to IV route. Lumbar sympathetic blockade also produced significant reduction in pain intensity compared to pretreatment values of allodynia to brush, pinprick and pinprick temporal summation and verbal pain scores. IV lidocaine did not produce significant changes in spontaneous and evoked pain intensity measurements compared to pretreatment values. There were no carryover effects as assessed by route-by-period interaction.
conclusionsUnder the conditions of this study, the results provide some direct evidence that a component of pain may be mediated by abnormal sympathetic efferent activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.