ArticleCancer genetics and cytogenetics2009
Molecular inversion probes reveal patterns of 9p21 deletion and copy number aberrations in childhood leukemia.
Article in Cancer genetics and cytogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Homozygous deletion mapping in myeloma samples identifies genes and an expression signature relevant to pathogenesis and outcome.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Trial
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- Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study.BMC genomics · 2017Article
- DNA copy number analysis of Grade II-III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status.Acta neuropathologica communications · 2015Article
- MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing.Bioinformatics (Oxford, England) · 2014Article
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- DREAMing of a patent-free human genome for clinical sequencing.Nature biotechnology · 2013Article
- The glucocorticoid receptor gene polymorphism N363S predisposes to more severe toxic side effects during pediatric acute lymphoblastic leukemia (ALL) therapy.International journal of hematology · 2013Article
- Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors.Genes, chromosomes & cancer · 2013Article
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- Article
- Genome wide copy number analysis of paediatric Burkitt lymphoma using formalin-fixed tissues reveals a subset with gain of chromosome 13q and corresponding miRNA over expression.British journal of haematology · 2011Article
- Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.Neuro-oncology · 2011Article
- Article
- Clonal Relationship Between Lichen Sclerosus, Differentiated Vulvar Intra-epithelial Neoplasia and Non HPV-related Vulvar Squamous Cell Carcinoma.Cancer genomics & proteomicsArticle
- Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma.Cancer geneticsArticle
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Childhood leukemia, which accounts for >30% of newly diagnosed childhood malignancies, is one of the leading causes of death for children with cancer. Genome-wide studies using microarray chips to identify copy number changes in human cancer are becoming more common. In this pilot study, 45 pediatric leukemia samples were analyzed for gene copy aberrations using novel molecular inversion probe (MIP) technology. Acute leukemia subtypes included precursor B-cell acute lymphoblastic leukemia (ALL) (n=23), precursor T-cell ALL (n=6), and acute myeloid leukemia (n=14). The MIP analysis identified 69 regions of recurring copy number changes, of which 41 have not been identified with other DNA microarray platforms. Copy number gains and losses were validated in 98% of clinical karyotypes and 100% of fluorescence in situ hybridization studies available. We report unique patterns of copy number loss in samples with 9p21.3 (CDKN2A) deletion in the precursor B-cell ALL patients, compared with the precursor T-cell ALL patients. MIPs represent an attractive technology for identifying novel copy number aberrations, validating previously reported copy number changes, and translating molecular findings into clinically relevant targets for further investigation.
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