ArticleItalian journal of pediatrics2009
Metabolic Bone Disease in preterm newborn: an update on nutritional issues.
Article in Italian journal of pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Pooled it
- Pooled it
- Could low birth weight and preterm birth be associated with significant burden of hip osteoarthritis? A systematic review.Arthritis research & therapy · 2018Pooled it
- Calcium and phosphorus supplementation of human milk for preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Narrative review of human milk fortifiers for preterm infants.Frontiers in pediatrics · 2026Review
- Biochemical markers for metabolic bone disease in preterm infants: insights from a structured Bone Health Programme in the Middle East.BMJ paediatrics open · 2025Article
- Metabolic bone disease in extremely preterm infants: incidence, risk factors, and outcomes from a structured bone health program.Frontiers in pediatrics · 2025Article
- First-trimester nutrition insights from the United Arab Emirate Birth Cohort Study (UAE-BCS): assessment of dietary intake, micronutrient profiles, and folic acid supplementation in Emirati Women.Journal of nutritional science · 2025Article
- Invited Mini Review Metabolic Bone Disease of Prematurity: Overview and Practice Recommendations.Hormone research in paediatrics · 2025Review
- Role of fibroblast growth factor-23 as an early marker of metabolic bone disease of prematurity.BMC pediatrics · 2024Observational
- Diagnostics of Metabolic Bone Disease in Extremely Preterm Infants-Clinical Applicability of Bone Turnover Biochemical Markers and Quantitative Ultrasound.Children (Basel, Switzerland) · 2024Article
- Biomarkers and Biochemical Indicators to Evaluate Bone Metabolism in Preterm Neonates.Biomedicines · 2024Article
- Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age.Children (Basel, Switzerland) · 2024Article
- Narrative review of methodological advances in human milk fortification: for better preterm infant growth.Frontiers in pediatrics · 2024Review
- Effects of two-stage preterm formulas on growth, nutritional biomarkers, and neurodevelopment in preterm infants.Frontiers in pediatrics · 2024Article
- Asymptomatic Infant Rib Fractures Are Primarily Non-abuse-Related and Should Not Be Used to Assess Physical Child Abuse.Children (Basel, Switzerland) · 2023Article
- Effects of early introduction of solid foods on nutrient intake in preterm infants during their 1st year of life: a secondary outcome analysis of a prospective, randomized intervention study.Frontiers in nutrition · 2023Article
- Vitamin D, bone density, and nephrocalcinosis in preterm infants: a prospective study.Pediatric nephrology (Berlin, Germany) · 2022Observational
- Hormonal regulation of biomineralization.Nature reviews. Endocrinology · 2021Review
- Update on Calcium and Phosphorus Requirements of Preterm Infants and Recommendations for Enteral Mineral Intake.Nutrients · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteopenia, a condition characterised by a reduction in bone mineral content, is a common disease of preterm babies between the tenth and sixteenth week of life. Prematurely born infants are deprived of the intrauterine supply of minerals affecting bone mineralization.The aetiology is multifactorial: inadequate nutrients intake (calcium, phosphorus and vitamin D), a prolonged period of total parenteral nutrition, immobilisation and the intake of some drugs.The diagnosis of metabolic bone disease is done by biochemical analysis: low serum levels of phosphorus and high levels of alkaline phosphatase are suggestive of metabolic bone disease. The disease can remain clinically silent or presents with symptoms and signs of rachitism depending on the severity of bone demineralisation.An early nutritional intervention can reduce both the prevalence and the severity of osteopenia.This article reviews the pathophysiology of foetal and neonatal bone metabolism, focuses on the nutrient requirements of premature babies and on the ways to early detect and treat osteopenia.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.