ArticleWorld journal of gastroenterology2009
Thermal hypersensitivity in a subset of irritable bowel syndrome patients.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Subtyping irritable bowel syndrome using cluster analysis: a systematic review.BMC bioinformatics · 2023Pooled it
- Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome.The journal of pain · 2011Trial
- Crohn's disease, irritable bowel syndrome, and chronic fatigue: the importance of communication and symptom management-a case report.Journal of medical case reports · 2025Article
- A neuropsychosocial signature predicts longitudinal symptom changes in women with irritable bowel syndrome.Molecular psychiatry · 2022Article
- Supraspinal Mechanisms of Intestinal Hypersensitivity.Cellular and molecular neurobiology · 2022Review
- Experimental Pain Sensitivity in Subjects with Temporomandibular Disorders and Multiple Other Chronic Pain Conditions: The OPPERA Prospective Cohort Study.Journal of oral & facial pain and headache · 2020Article
- The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations.The journal of pain · 2017Review
- Characteristics of sensitization associated with chronic pain conditions.The Clinical journal of pain · 2014Article
- Lesioning of TRPV1 expressing primary afferent neurons prevents PAR-2 induced motility, but not mechanical hypersensitivity in the rat colon.Neurogastroenterology and motility · 2012Article
- The effect of topical local anesthetics on thermal pain sensitivity in patients with irritable bowel syndrome.Pain research and treatment · 2012Article
- A mechanism-based approach to prevention of and therapy for fibromyalgia.Pain research and treatment · 2012Article
- Ischemic hypersensitivity in irritable bowel syndrome patients.Pain medicine (Malden, Mass.) · 2010Article
- Article
- Relationships between Irritable Bowel Syndrome Pain, Skin Temperature Indices of Autonomic Dysregulation, and Sensitivity to Thermal Cutaneous Stimulation.Pain research and treatment · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
aimTo characterize thermal hypersensitivity in patients with constipation- and diarrhea-predominant irritable bowel syndrome (IBS).
methodsThermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects. A total of 42 patients (29 female and 13 male; mean age 27.0 +/- 6.4 years) with D-IBS; 24 patients (16 female and eight male; mean age 32.5 +/- 8.8 years) with C-IBS; and 52 control subjects (34 female and 18 male; mean age 27.3 +/- 8.0 years) participated in the study. Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm x 3 cm surface area. Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits. The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.
resultsControls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo. Thermal hyperalgesia was present in both groups of IBS patients relative to controls, with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites. Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia. One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls; a second cluster (47% of the sample) showed moderate heat pain sensitivity; and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.
conclusionA subset of IBS patients had thermal hypersensitivity compared to controls, who reported significantly lower HPTh and HPTo. All IBS patients had a higher score on the FBDSI than controls. Interestingly, the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients.
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