ReviewCell motility and the cytoskeleton2009
The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions.
Review in Cell motility and the cytoskeleton, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed.
- Cooperative multivalency converts disorder into rods, resolving a paradox in cellular architecture.bioRxiv : the preprint server for biology · 2026Article
- Article
- Calpain Small Subunit Mediated Secretion of Galectin-3 Regulates Traction Stress.Biomedicines · 2024Article
- Integration of Transcriptomics and Non-Targeted Metabolomics Reveals the Underlying Mechanism of Skeletal Muscle Development in Duck during Embryonic Stage.International journal of molecular sciences · 2023Article
- MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis.Cell adhesion & migration · 2021Article
- A computational model of mutual antagonism in the mechano-signaling network of RhoA and nitric oxide.BMC molecular and cell biology · 2021Article
- Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates.Journal of cell science · 2021Article
- Growth factor dependent changes in nanoscale architecture of focal adhesions.Scientific reports · 2021Article
- Focal adhesion clustering drives endothelial cell morphology on patterned surfaces.Journal of the Royal Society, Interface · 2019Article
- The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly.Scientific reports · 2019Article
- Live cell imaging reveals focal adhesions mechanoresponses in mammary epithelial cells under sustained equibiaxial stress.Scientific reports · 2018Article
- Mature and progenitor endothelial cells perform angiogenesis also under protease inhibition: the amoeboid angiogenesis.Journal of experimental & clinical cancer research : CR · 2018Article
- Holographic Traction Force Microscopy.Scientific reports · 2018Article
- Quantitative analysis of focal adhesion dynamics using photonic resonator outcoupler microscopy (PROM).Light, science & applications · 2018Article
- Article
- Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase.Nature communications · 2016Article
- Cell adhesion and invasion mechanisms that guide developing axons.Current opinion in neurobiology · 2016Review
- The actin crosslinking protein palladin modulates force generation and mechanosensitivity of tumor associated fibroblasts.Scientific reports · 2016Article
- EGF-induced dynamics of NF-κB and F-actin in A431 cells spread on fibronectin.Histochemistry and cell biology · 2015Article
- Binding of the WASP/N-WASP-interacting protein WIP to actin regulates focal adhesion assembly and adhesion.Molecular and cellular biology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Focal adhesions (FAs) are large clusters of transmembrane receptors of the integrin family and a multitude of associated cytoplasmic "plaque" proteins, which connect the extracellular matrix-bound receptors with the actin cytoskeleton. The formation of nearly stationary FAs defines a boundary between the dense and highly dynamic actin network in lamellipodium and the sparser and more diverse cytoskeletal organization in the lamella proper, creating a template for the organization of the entire actin network. The major "mechanical" and "sensory" functions of FAs; namely, the nucleation and regulation of the contractile, myosin-II-containing stress fibers and the mechanosensing of external surfaces depend, to a major extent, on the dynamics of molecular components within FAs. A central element in FA regulation concerns the positive feedback loop, based on the most intriguing feature of FAs; that is, their dependence on mechanical tension developing by the growing stress fibers. FAs grow in response to such tension, and rapidly disassemble upon its relaxation. In this article, we address the mechanistic relationships between the process of FA development, maturation and dissociation and the dynamic molecular events, which take place in different regions of the FA, primarily in the distal end of this structure (the "toe") and the proximal "heel," and discuss the central role of local mechanical forces in orchestrating the complex interplay between FAs and the actin system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.