ArticleArchives of neurology2009
Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships.
Article in Archives of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Interactive Association Between Intronic Polymorphism (rs10506151) of the LRRK2 Gene and Type 2 Diabetes on Neurodegenerative Diseases.Pharmacogenomics and personalized medicine · 2021Article
- The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus.Human genetics · 2019Article
- Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities.Neurology. Genetics · 2017Article
- Associations of Brain Structure With Adiposity and Changes in Adiposity in a Middle-Aged and Older Biracial Population.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Multiple Factors Involved in the Pathogenesis of White Matter Lesions.BioMed research international · 2017Review
- Blood and CSF biomarkers in brain subcortical ischemic vascular disease: Involved pathways and clinical applicability.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Review
- Genetic profiles in ischaemic stroke.Current atherosclerosis reports · 2013Review
- Genetics of age-related white matter lesions from linkage to genome wide association studies.Journal of the neurological sciences · 2012Review
- Genetics of subcortical vascular dementia.Experimental gerontology · 2012Review
- Co-occurrence of parkinsonism and dementia in clinical practice: relevant differential diagnoses.Zeitschrift fur Gerontologie und Geriatrie · 2012Article
- The genetics of white matter lesions.CNS neuroscience & therapeutics · 2011Review
- Risk factor profile for chronic kidney disease is similar to risk factor profile for small artery disease.Journal of hypertension · 2011Article
- Genetic susceptibility to ischemic stroke.Nature reviews. Neurology · 2011Review
- Genetics of common polygenic ischaemic stroke: current understanding and future challenges.Stroke research and treatment · 2011Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo localize susceptibility genes for alterations in brain structure associated with risk of stroke and dementia. We conducted genomewide linkage analyses for magnetic resonance imaging (MRI) measures of brain atrophy, ventricular, and subcortical white matter hyperintensity (leukoaraiosis) in 689 non-Hispanic white (673 sibling pairs; median age, 61 years) and 544 non-Hispanic black participants (503 sibling pairs; median age, 64 years) from sibships with at least 2 members with essential hypertension. DESIGN, SETTING, AND PATIENTS: We determined brain, ventricular, and leukoaraiosis volumes from axial fluid-attenuated inversion recovery MRI; we calculated brain atrophy as the difference between total intracranial and brain volumes. Microsatellite markers (n = 451) distributed across the 22 autosomes were genotyped, and we used variance components methods to estimate heritability and assess evidence of genetic linkage for each MRI measure.
main outcome measuresBrain atrophy ventricular volume, and leukoaraiosis determined from fluid-attenuated inversion recovery MRI.
resultsIn both races, the heritability of each MRI measure was statistically greater than 0 (P < .001), ranging in magnitude from 0.42 (for ventricular volume in blacks) to 0.69 (for brain atrophy in blacks). Based on multipoint logarithm of odds scores (MLS), the strongest evidence of genetic linkage was observed for brain atrophy on chromosomes 1 (MLS, 3.49 at 161 cM; P < .001) and 17 (MLS, 3.08 at 18 cM; P < .001) in whites; for ventricular volume on chromosome 12 (MLS, 3.67 at 49 cM; P < .001) in blacks and chromosome 10 (MLS, 2.47 at 110 cM; P < .001) in whites; and for leukoaraiosis on chromosome 11 (MLS, 2.21 at 118 cM; P < .001) in whites and chromosome 22 (MLS, 2.02 at 36 cM; P = .001) in blacks.
conclusionsThe MRI measures of structural brain injury are heritable in non-Hispanic black and white sibships ascertained through hypertensive sibling pairs. The susceptibility loci for brain atrophy, ventricular volume, and leukoaraiosis identified by linkage analyses differ among MRI measures and between races.
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