ArticleDiabetologia1991
Effect of insulin-like growth factor I infusion on renal hypertrophy in experimental diabetes mellitus in rats.
Article in Diabetologia, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of long-term experimental diabetes on adrenal gland growth and phosphoribosyl pyrophosphate formation in growth hormone-deficient dwarf rats.International journal of experimental pathology · 2012Article
- Effects of long-acting somatostatin analogues on adrenal growth and phosphoribosyl pyrophosphate formation in experimental diabetes.International journal of experimental pathology · 2012Article
- Identification of compounds that inhibit IGF-I signaling in hyperglycemia.Experimental diabetes research · 2009Article
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4 authors at 1 institution in 1 country.
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Abstract
Initial diabetic renal hypertrophy is preceded by a transient increase in kidney insulin-like growth factor I suggesting that insulin-like growth factor I may be implicated in diabetic kidney growth. The present study was undertaken to examine the effects of exogenous insulin-like growth factor I infusion on diabetic renal hypertrophy at a time when renal insulin-like growth factor I concentration had returned to normal and the initial steep kidney growth rate had diminished to a much slower rate. Groups of rats with diabetes duration of 5 days were infused s.c. for 4 subsequent days with equimolar concentrations of insulin-like growth factor I (36 nmol/day) or insulin (35 nmol/day). Insulin infusion lowered blood glucose to a normal level within 2 days and induced an average body-weight gain of 9.3 +/- 0.6 g/day. Insulin-like growth factor I infused diabetic rats maintained the original diabetic state with blood glucose levels comparable to those of 0.154 mol/l NaCl-infused diabetic rats, but had nevertheless an average body-weight gain of 6.8 +/- 1.0 g/day while untreated diabetic rats had a lower body-weight gain amounting to 3.3 +/- 0.8 g/day (p less than 0.01). The kidney weight at day 9 in untreated diabetic animals was about 25% greater than that of non-diabetic control animals, while in insulin-like growth factor I treated diabetic rats a further increase (p less than 0.05) was seen, amounting to 36% above control level. No increase was seen in the insulin-treated diabetic group.(ABSTRACT TRUNCATED AT 250 WORDS)
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