ArticleGenetics2009
The action of purifying selection, mutation and drift on fitness epistatic systems.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Genetic architecture of growth traits revealed by global epistatic interactions.Genome biology and evolution · 2011Pooled it
- Purging of deleterious burden in the endangered Iberian lynx.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Accelerated inbreeding depression suggests synergistic epistasis for deleterious mutations in Drosophila melanogaster.Heredity · 2019Article
- Inferring the Nature of Missing Heritability in Human Traits Using Data from the GWAS Catalog.Genetics · 2019Article
- Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations.Heredity · 2018Article
- Circular mating as an option for the genetic management of captive populations: response to Caballero et al.Heredity · 2017Article
- Inbreeding load and purging: implications for the short-term survival and the conservation management of small populations.Heredity · 2017Article
- On the Consequences of Purging and Linkage on Fitness and Genetic Diversity.G3 (Bethesda, Md.) · 2015Article
- Dynamic epistasis under varying environmental perturbations.PloS one · 2015Article
- The biology of small, introduced populations, with special reference to biological control.Evolutionary applications · 2012Article
- Current applications of models of genetic effects with interactions across the genome.Current genomics · 2012Article
- Understanding and predicting the fitness decline of shrunk populations: inbreeding, purging, mutation, and standard selection.Genetics · 2012Article
- The fuel of evolution.Heredity · 2011Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For different fitness mutational models, with epistasis introduced, we simulated the consequences of drift (D scenario) or mutation, selection, and drift (MSD scenario) in populations at the MSD balance subsequently subjected to bottlenecks of size N = 2, 10, 50 during 100 generations. No "conversion" of nonadditive into additive variance was observed, all components of the fitness genetic variance initially increasing with the inbreeding coefficient F and subsequently decreasing to zero (D) or to an equilibrium value (MSD). In the D scenario, epistasis had no appreciable effect on inbreeding depression and that on the temporal change of variance components was relevant only for high rates of strong epistatic mutation. In parallel, between-line differentiation in mean fitness accelerated with F and that in additive variance reached a maximum at F approximately 0.6-0.7, both processes being intensified by strong epistasis. In the MSD scenario, however, the increase in additive variance was smaller, as it was used by selection to purge inbreeding depression (N > or = 10), and selection prevented between-line differentiation. Epistasis, either synergistic or antagonistic (this leading to multiple adaptive peaks), had no appreciable effect on MSD results nor, therefore, on the evolutionary rate of fitness change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.