ArticleThe Journal of physiology2009
Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- The Effect of Lower Limb Combined Neuromuscular Electrical Stimulation on Skeletal Muscle Signaling for Glucose Utilization, Myofiber Distribution, and Metabolic Function after Spinal Cord Injury.International journal of environmental research and public health · 2023Trial
- Training in the fasted state improves glucose tolerance during fat-rich diet.The Journal of physiology · 2010Trial
- Skeletal Muscle Effects of GLP 1 Receptor Agonists: Molecular Mechanisms and Comparative Insights on Semaglutide and Tirzepatide, a Narrative Review.International journal of molecular sciences · 2026Review
- Antioxidants and Sports Performance.Nutrients · 2023Review
- The Impact of Skeletal Muscle ERα on Mitochondrial Function and Metabolic Health.Endocrinology · 2020Review
- The impact of ERα action on muscle metabolism and insulin sensitivity - Strong enough for a man, made for a woman.Molecular metabolism · 2018Review
- Control of Muscle Metabolism by the Mediator Complex.Cold Spring Harbor perspectives in medicine · 2018Review
- Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α.The Journal of biological chemistry · 2016Article
- Activation of AMP-Activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells.PloS one · 2016Article
- Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome.Molecular and cellular endocrinology · 2015Review
- The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice.Molecular metabolism · 2015Article
- CaMKII content affects contractile, but not mitochondrial, characteristics in regenerating skeletal muscle.BMC physiology · 2014Article
- Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists.PloS one · 2014Article
- Skeletal muscle signaling associated with impaired glucose tolerance in spinal cord-injured men and the effects of contractile activity.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- The role of estrogens in control of energy balance and glucose homeostasis.Endocrine reviews · 2013Review
- Adaptations in muscle metabolic regulation require only a small dose of aerobic-based exercise.European journal of applied physiology · 2013Article
- Article
- Genomics and genetics in the biology of adaptation to exercise.Comprehensive Physiology · 2011Review
- In vivo stimulation of oestrogen receptor α increases insulin-stimulated skeletal muscle glucose uptake.The Journal of physiology · 2011Article
- Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARγ.Stem cells and development · 2010Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased glucose transporter GLUT4 expression in skeletal muscle is an important benefit of regular exercise, resulting in improved insulin sensitivity and glucose tolerance. The Ca(2+)-calmodulin-dependent kinase II (CaMKII), calcineurin and AMPK pathways have been implicated in GLUT4 gene regulation based on pharmacological evidence. Here, we have used a more specific genetic approach to establish the relative role of the three pathways in fast and slow muscles. Plasmids coding for protein inhibitors of CaMKII or calcineurin were co-transfected in vivo with a GLUT4 enhancer-reporter construct either in normal mice or in mice expressing a kinase dead (KD) AMPK mutant. GLUT4 reporter activity was not inhibited in the slow soleus muscle by blocking either CaMKII or calcineurin alone, but was inhibited by blocking both pathways. GLUT4 reporter activity was likewise unchanged in the soleus of KD-AMPK mice, but was significantly reduced by incapacitation of either CaMKII or calcineurin in these mice. On the other hand, in the fast tibialis anterior (TA) muscle, calcineurin appears to exert a prominent role in the control of GLUT4 reporter activity, independent of CaMKII and AMPK. The results point to a muscle type-specific and redundant regulation of GLUT4 enhancer based on the interplay of multiple signalling pathways, all of which are known to affect myocyte enhancing factor 2 (MEF2) transcriptional activity, a point of convergence of different pathways on muscle gene regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.