ArticleNucleic acids research2009
LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
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- Comparative Evaluation of Adsorption of Major Enzymes in a Cellulase Cocktail Obtained fromPolymers · 2022Article
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- Effects of targeting sumoylation processes during latent and induced Epstein-Barr virus infections using the small molecule inhibitor ML-792.Antiviral research · 2021Article
- Emerging Roles of LSM Complexes in Posttranscriptional Regulation of Plant Response to Abiotic Stress.Frontiers in plant science · 2019Review
- RNA-binding proteins with prion-like domains in health and disease.The Biochemical journal · 2017Review
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- Neutrophil transcriptional profile changes during transit from bone marrow to sites of inflammation.Cellular & molecular immunology · 2015Article
- Glycation of apoprotein A-I is associated with coronary artery plaque progression in type 2 diabetic patients.Diabetes care · 2013Article
- RNA degradation in Saccharomyces cerevisae.Genetics · 2012Review
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- Expression of Ixodes scapularis antifreeze glycoprotein enhances cold tolerance in Drosophila melanogaster.PloS one · 2012Article
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- Suppression of Ycf1p function by Cka1p-dependent phosphorylation is attenuated in response to salt stress.FEMS yeast research · 2010Article
- Decapping activators in Saccharomyces cerevisiae act by multiple mechanisms.Molecular cell · 2010Article
- Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks.The Journal of experimental medicine · 2010Article
- 3' processing of eukaryotic precursor tRNAs.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Lsm1 is a component of the Lsm1-7 complex involved in cytoplasmic mRNA degradation. Lsm1 is over-expressed in multiple tumor types, including over 80% of pancreatic tumors, and increased levels of Lsm1 protein have been shown to induce carcinogenic effects. Therefore, understanding the perturbations in cell process due to increased Lsm1 protein may help to identify possible therapeutics targeting tumors over-expressing Lsm1. Herein, we show that LSM1 over-expression in the yeast Saccharomyces cerevisiae inhibits growth primarily due to U6 snRNA depletion, thereby altering pre-mRNA splicing. The decrease in U6 snRNA levels causes yeast strains over-expressing Lsm1 to be hypersensitive to loss of other proteins required for production or function of the U6 snRNA, supporting a model wherein excess Lsm1 reduces the availability of the Lsm2-7 proteins, which also assemble with Lsm8 to form a complex that binds and stabilizes the U6 snRNA. Yeast strains over-expressing Lsm1 also display minor alterations in mRNA decay and demonstrate increased susceptibility to mutations inhibiting cytoplasmic deadenylation, a process required for both 5'-to-3' and 3'-to-5' pathways of exonucleolytic decay. These results suggest that inhibition of splicing and/or deadenylation may be effective therapies for Lsm1-over-expressing tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.