ArticleMolecular and cellular biology2009
The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 62 citations in OpenAlex.
- p27Cells · 2025Article
- Review
- The emerging role of microtubules in invasion plasticity.Frontiers in oncology · 2023Review
- p27International journal of molecular sciences · 2022Article
- Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer.Cell reports · 2021Article
- Development of human prostate cancer stem cells involves epigenomic alteration and PI3K/AKT pathway activation.Experimental hematology & oncology · 2020Article
- Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells.Nature reviews. Cancer · 2019Review
- Effect of hydrogel stiffness on morphology and gene expression pattern of CD44International journal of clinical and experimental pathology · 2019Article
- p27kip1 at the crossroad between actin and microtubule dynamics.Cell division · 2019Article
- Mapping Interactions between p27 and RhoA that Stimulate Cell Migration.Journal of molecular biology · 2018Article
- Landscape of CDKN1B Mutations in Luminal Breast Cancer and Other Hormone-Driven Human Tumors.Frontiers in endocrinology · 2018Review
- Modes of invasion during tumour dissemination.Molecular oncology · 2017Review
- p27kip1 expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms.Oncotarget · 2016Article
- Snail levels control the migration mechanism of mesenchymal tumor cells.Oncology letters · 2016Article
- The non-canonical functions of p27(Kip1) in normal and tumor biology.Cell cycle (Georgetown, Tex.) · 2016Review
- Meet me in the cytoplasm: A role for p27(Kip1) in the control of H-Ras.Small GTPases · 2016Review
- Genetic analysis of ovarian microcystic stromal tumor.Obstetrics & gynecology science · 2016Article
- SUMOylation regulates p27Kip1 stability and localization in response to TGFβ.Journal of molecular cell biology · 2016Article
- High RhoA expression at the tumor front in clinically localized prostate cancer and association with poor tumor differentiation.Oncology letters · 2016Article
- Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces.Clinical & experimental metastasis · 2016Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many human cancers, p27 downregulation correlates with a worse prognosis, suggesting that p27 levels could represent an important determinant in cell transformation and cancer development. Using a mouse model system based on v-src-induced transformation, we show here that p27 absence is always linked to a more aggressive phenotype. When cultured in three-dimensional contexts, v-src-transformed p27-null fibroblasts undergo a morphological switch from an elongated to a rounded cell shape, accompanied by amoeboid-like morphology and motility. Importantly, the acquisition of the amoeboid motility is associated with a greater ability to move and colonize distant sites in vivo. The reintroduction of different p27 mutants in v-src-transformed p27-null cells demonstrates that the control of cell proliferation and motility represents two distinct functions of p27, both necessary for it to fully act as a tumor suppressor. Thus, we highlight here a new p27 function in driving cell plasticity that is associated with its C-terminal portion and does not depend on the control of cyclin-dependent kinase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.