ReviewMolecular oncology2009
Endocytosis and signalling: a meeting with mathematics.
Review in Molecular oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Spatiotemporal modeling of GPCR signaling: The role of endosomal dynamics and receptor recycling.PLoS computational biology · 2026Article
- Endocytic turnover of endothelial cell-membrane proteins as a driver of rat blood-brain barrier specialization and dysfunction.iScience · 2026Article
- An Asymptotic Analysis of Bivalent Monoclonal Antibody-Antigen Binding.Bulletin of mathematical biology · 2025Article
- Understanding antibody-target antigen interactions and the avidity effect using mathematical modelling.Journal of the Royal Society, Interface · 2025Article
- Targeted Quantification of Protein Phosphorylation and Its Contributions towards Mathematical Modeling of Signaling Pathways.Molecules (Basel, Switzerland) · 2023Review
- The Cytoskeleton in Plant Immunity: Dynamics, Regulation, and Function.International journal of molecular sciences · 2022Review
- Modelling the impact of nucleolin expression level on the activity of F3 peptide-targeted pH-sensitive pegylated liposomes containing doxorubicin.Drug delivery and translational research · 2022Article
- Correlated receptor transport processes buffer single-cell heterogeneity.PLoS computational biology · 2017Article
- Therapy operating characteristic curves: tools for precision chemotherapy.Journal of medical imaging (Bellingham, Wash.) · 2016Article
- Quantifying and Reducing Uncertainties in Cancer Therapy.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- Intracellular regulation of cell signaling cascades: how location makes a difference.Journal of mathematical biology · 2014Article
- Reconstruction and analysis of nutrient-induced phosphorylation networks in Arabidopsis thaliana.Frontiers in plant science · 2013Article
- Signaling regulated endocytosis and exocytosis lead to mating pheromone concentration dependent morphologies in yeast.FEBS letters · 2012Article
- Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Physiological reviews · 2012Review
- Trafficking coordinate description of intracellular transport control of signaling networks.Biophysical journal · 2011Article
- A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.Developmental cell · 2011Article
- Spatial aspects in biological system simulations.Methods in enzymology · 2011Article
- Age-related changes in scavenger receptor-mediated endocytosis in rat liver sinusoidal endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010Article
- The endocytic matrix.Nature · 2010Review
- Endocytosis and signalling: a meeting with mathematics.Molecular oncology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Although endocytosis has traditionally been understood as a signal attenuation mechanism, an emerging view considers endocytosis as an integral part of signal propagation and processing. On the short time scale, trafficking of endocytic vesicles contributes to signal propagation from the surface to distant targets, with bi-directional communication between signalling and trafficking. Mathematical modelling helps combine the mechanistic, molecular knowledge with rigorous analysis of the complex output dynamics of endocytosis in time and space. Simulations reveal novel roles for endocytosis, including the control of cell polarity, enhancing the spatial signal propagation, and controlling the signal magnitudes, kinetics, and synchronization with stimulus dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.