ArticleNeuroscience research2009
Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures.
Article in Neuroscience research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- The Intricate Relationship of Trk Receptors in Brain Diseases and Disorders.Molecular neurobiology · 2025Review
- Electroconvulsive therapy for obsessive-compulsive disorder: clinical efficacy and predictive role of inflammatory markers.Frontiers in psychiatry · 2025Article
- Electroconvulsive therapy in the Fourth Industrial Revolution (Review).Biomedical reports · 2024Review
- Glial Purinergic Signals and Psychiatric Disorders.Frontiers in cellular neuroscience · 2021Review
- Neurotrophin signalling in amygdala-dependent cued fear learning.Cell and tissue research · 2020Review
- Electroconvulsive stimulation attenuates chronic neuroinflammation.JCI insight · 2020Article
- Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and ameliorated schizophrenia-like behavior of Gunn rat.Journal of neuroinflammation · 2016Article
- Electroconvulsive seizures (ECS) do not prevent LPS-induced behavioral alterations and microglial activation.Journal of neuroinflammation · 2015Article
- Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test.Pharmacognosy research · 2012Article
- The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice.Neurochemical research · 2011Article
- Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Effects of repeated minimal electroshock seizures on NGF, BDNF and FGF-2 protein in the rat brain during postnatal development.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2010Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Repeated (but not acute) exposure to brief, non-injurious seizures evoked by minimal electroconvulsive shock (ECS) decreases neuronal death in limbic system and increases mRNA levels for nerve growth factor (NGF). Thus, the induction of NGF is a potential mechanism for the neuroprotection evoked by repeated ECS. The neuroprotective action of NGF is mediated by the TrkA receptor. This study determined whether repeated ECS exposure increased TrkA and NGF protein levels. To determine the functional significance of changes in these proteins, we compared the effects of ECS given daily either for 7 days (chronic ECS) or for 1 day (acute ECS). After chronic ECS, upregulation of both NGF and TrkA was found in perirhinal cortex, thalamus, and amygdala. In hippocampus, TrkA was upregulated in CA2, CA3 and CA4. NGF increase in hippocampus was found in CA1 and dentate gyrus. In frontal cortex and substantia innominata, an increase in NGF (but not in TrkA) was found. In most brain regions, TrkA and NGF remained unchanged after acute ECS. Our results demonstrate that repeated exposure to ECS causes an upregulation of TrkA and NGF proteins in several limbic areas in which neuroprotective effects are observed suggesting that NGF contributes to ECS-evoked neuroprotection.
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Registered trials
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