Evidence map›Paper›PMID 19596370›Full record

ArticleNeurotoxicology2009

Animal models of autism spectrum disorders: information for neurotoxicologists.

Alycia K Halladay, David Amaral, Michael Aschner, Valerie J Bolivar, Aaron Bowman, Emanuel DiCicco-Bloom, Susan L Hyman, Flavio Keller, Pamela Lein, Isaac Pessah and 2 more

Open access · greenAbstract read
In one paragraph

Article in Neurotoxicology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Altered Caecal Neuroimmune Interactions in the Neuroligin-3Frontiers in cellular neuroscience · 2020
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Changing concepts and findings on autism.Journal of autism and developmental disorders · 2013
    Review
  12. Article
  13. Article
  14. Article
  15. The autism diagnosis in translation: shared affect in children and mouse models of ASD.Autism research : official journal of the International Society for Autism Research · 2011
    Review
  16. Article
  17. Mouse models of autism: testing hypotheses about molecular mechanisms.Current topics in behavioral neurosciences · 2011
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Alycia K HalladayAutism Speaks, 2 Park Avenue, 4th Floor, New York, NY 10016, United States. ahalladay@autismspeaks.org
David Amaral
Michael Aschner
Valerie J Bolivar
Aaron Bowman
Emanuel DiCicco-Bloom
Susan L Hyman
Flavio Keller
Pamela Lein
Isaac Pessah
Linda Restifo
David W Threadgill
University of California, Davis · USVanderbilt University · USAutism Speaks · USNorth Carolina State University · USRutgers, The State University of New Jersey · USState Key Laboratory of NeuroscienceUniversity of Arizona · USUniversity of Rochester · USWadsworth Center · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
Molecular and Cellular Basis of PCB Developmental Neurotoxicity: ViCTER supplementR01ES014901 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HANS-JOACHIM LEHMLER, Pamela J Lein · 2009 to 2026
$9.3M
NEUROTOXICANT EFFECTS ON CELL CYCLE REGULATION OF NEUROGENESISP01ES011256 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI LAMBERT, GEORGE H · 2001 to 2005
$3.3M
Identification and Functional Assessment of Autism Susceptibility GenesR01MH076624 · NIMH · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI MILLONIG, JAMES H. · 2005 to 2009
$2.1M
Genetics of complex behaviors in the mouse.R01MH068013 · NIMH · WADSWORTH CENTER · PI BOLIVAR, VALERIE J · 2003 to 2007
$1.7M
Retrograde Dystrophic Influence of IFN-gamma on NeuronsR01NS046649 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEIN, PAMELA J · 2003 to 2006
$1.0M
Genetics of spatial learning and memoryR21MH067850 · NIMH · WADSWORTH CENTER · PI BOLIVAR, VALERIE J · 2004 to 2005
$362k
Molecular and Cellular Basis of PCB Developmental NeurotoxicityR56ES014901 · NIEHS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEIN, PAMELA J · 2007 to 2007
$150k
Wnt Regulation of Cell Cycle in Cortical NeurogenesisF30NS048649 · NINDS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ROSSMAN, IAN T · 2004 to 2008
$139k
DOPAMINE ACTIONS IN THE NEOCORTICAL SLICEF32NS007331 · NINDS · STANFORD UNIVERSITY · PI MCCORMICK, DAVID A · 1986 to 1986
–
NIEHS NIH HHS 1R01ES014901NIEHS NIH HHS ES014901NIEHS NIH HHS ES11256NIEHS NIH HHS P01 ES011256NIEHS NIH HHS P01ES011269NIEHS NIH HHS P42 ES004699NIEHS NIH HHS P42ES04699NIEHS NIH HHS R01 ES014901NIEHS NIH HHS R56 ES014901NIMH NIH HHS MH067850NIMH NIH HHS MH076624NIMH NIH HHS R01 MH068013NIMH NIH HHS R01 MH076624NIMH NIH HHS R21 MH067850NINDS NIH HHS F30 NS048649NINDS NIH HHS NS048649NINDS NIH HHS NS07331NINDS NIH HHS NS46649NINDS NIH HHS R01 NS046649
6 · The paper itself

Abstract

Recent findings derived from large-scale datasets and biobanks link multiple genes to autism spectrum disorders. Consequently, novel rodent mutants with deletions, truncations and in some cases, overexpression of these candidate genes have been developed and studied both behaviorally and biologically. At the Annual Neurotoxicology Meeting in Rochester, NY in October of 2008, a symposium of clinicians and basic scientists gathered to present the behavioral features of autism, as well as strategies to model those behavioral features in mice and primates. The aim of the symposium was to provide researchers with up-to-date information on both the genetics of autism and how they are used in differing in vivo and in vitro animal models as well as to provide a background on the environmental exposures being tested on several animal models. In addition, researchers utilizing complementary approaches, presented on cell culture, in vitro or more basic models, which target neurobiological mechanisms, including Drosophila. Following the presentation, a panel convened to explore the opportunities and challenges of using model systems to investigate genetic and environment interactions in autism spectrum disorders. The following paper represents a summary of each presentation, as well as the discussion that followed at the end of the symposium.

Indexed as

Child Development Disorders, PervasiveGenetic Predisposition to DiseaseToxicologyAnimalsChildChild, PreschoolDisease Models, AnimalDrosophila melanogasterEnvironmentHumansMiceNeurotoxicity Syndromes

Identifiers

PMID19596370
PMCPMC3014989
OpenAlexW1974504871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.