ArticleFree radical biology & medicine2009
Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult.
Article in Free radical biology & medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Acute exercise increases resistance to oxidative stress in young but not older adults.Age (Dordrecht, Netherlands) · 2014Trial
- Tart cherry juice decreases oxidative stress in healthy older men and women.The Journal of nutrition · 2009Trial
- Sulforaphane improves exercise-induced NRF2 signaling in older adults: an in vivo-ex vivo approach.GeroScience · 2026Article
- Inflammageing and Cardiovascular System: Focus on Cardiokines and Cardiac-Specific Biomarkers.International journal of molecular sciences · 2023Review
- Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study.Age (Dordrecht, Netherlands) · 2016Article
- Assessment of Isoprostanes in Human Plasma: Technical Considerations and the Use of Mass Spectrometry.Lipids · 2016Review
- The isoprostanes--25 years later.Biochimica et biophysica acta · 2015Review
- Poised for success: implementation of sound conditioning strategies to promote endogenous protective responses to stroke in patients.Translational stroke research · 2013Review
- Oxidative stress in older adults: effects of physical fitness.Age (Dordrecht, Netherlands) · 2012Article
- Endothelial ischemia-reperfusion injury in humans: association with age and habitual exercise.American journal of physiology. Heart and circulatory physiology · 2011Article
- F2-isoprostanes as an indicator and risk factor for coronary heart disease.Free radical biology & medicine · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Age independently predicts poor outcome in a variety of medical settings, including sepsis, trauma, severe burns, and surgery. Because these conditions are associated with oxidative stress, we hypothesized that the capacity to constrain oxidative insult diminishes with age, leading to more extensive oxidative damage during trauma. To test this hypothesis, we used suprasystolic inflation of an arm blood pressure cuff to safely induce localized forearm ischemia/reperfusion (I/R) and quantified plasma F(2)-isoprostane (IsoP) levels in serial blood samples. Before I/R, IsoP levels were similar in young (20-33 years) and older adults (62-81 years). After I/R challenge, the magnitude and duration of increased IsoP levels was significantly greater in older adults. Because aging is associated with declining levels of sex hormones that contribute to the regulation of antioxidant enzyme expression, we then examined the response to I/R in older women receiving hormone replacement therapy and found that these women did not manifest the amplified IsoP response found in untreated older women. These findings demonstrate that aging impairs the ability to restrain oxidative damage after an acute insult, which may contribute to the increased vulnerability of older adults to traumatic conditions and establishes a useful method to identify effective interventions to ameliorate this deficiency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.