ArticleMolecular cell2009
Conformational changes associated with template commitment in ATP-dependent chromatin remodeling by ISW2.
Article in Molecular cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Article
- H2A.Z deposition by SWR1C involves multiple ATP-dependent steps.Nature communications · 2022Article
- Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes.Nature communications · 2021Article
- Article
- Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes.eLife · 2017Article
- Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler.Science (New York, N.Y.) · 2017Article
- A nucleotide-driven switch regulates flanking DNA length sensing by a dimeric chromatin remodeler.Molecular cell · 2015Article
- Quantitative determination of binding of ISWI to nucleosomes and DNA shows allosteric regulation of DNA binding by nucleotides.Biochemistry · 2014Article
- Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription.Nucleic acids research · 2014Article
- ISWI chromatin remodeling: one primary actor or a coordinated effort?Current opinion in structural biology · 2014Review
- ISWI chromatin remodeling complexes in the DNA damage response.Cell cycle (Georgetown, Tex.) · 2014Article
- Regulating the chromatin landscape: structural and mechanistic perspectives.Annual review of biochemistry · 2014Review
- No need for a power stroke in ISWI-mediated nucleosome sliding.EMBO reports · 2013Article
- Article
- Nucleosome sliding mechanisms: new twists in a looped history.Nature structural & molecular biology · 2013Review
- Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains.Nature structural & molecular biology · 2013Article
- The ATPase domain of ISWI is an autonomous nucleosome remodeling machine.Nature structural & molecular biology · 2013Article
- Epigenetic landscape of pluripotent stem cells.Antioxidants & redox signaling · 2012Review
- Disparity in the DNA translocase domains of SWI/SNF and ISW2.Nucleic acids research · 2012Article
- Swi2/Snf2 remodelers: hybrid views on hybrid molecular machines.Current opinion in structural biology · 2012Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Distinct stages in ATP-dependent chromatin remodeling are found as ISW2, an ISWI-type complex, forms a stable and processive complex with nucleosomes upon hydrolysis of ATP. There are two conformational changes of the ISW2-nucleosome complex associated with binding and hydrolysis of ATP. The initial binding of ISW2 to extranucleosomal DNA, to the entry site, and near the dyad axis of the nucleosome is enhanced by ATP binding, whereas subsequent ATP hydrolysis is required for template commitment and causes ISW2 to expand its interactions with nucleosomal DNA to an entire gyre of the nucleosome and a short approximately 3-4 bp site on the other gyre. The histone-fold-like subunit Dpb4 associates with nucleosomal DNA approximately 15 bp from the ATPase domain as part of this change and may help to disrupt histone-DNA interactions. These additional contacts are independent of the ATPase domain tracking along nucleosomal DNA and are maintained as ISW2 moves nucleosomes on DNA.
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