ArticleDrug and alcohol dependence2009
Diffusion tensor imaging in cocaine dependence: regional effects of cocaine on corpus callosum and effect of cocaine administration route.
Article in Drug and alcohol dependence, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Regional differences in white matter integrity in stimulant use disorders: A meta-analysis of diffusion tensor imaging studies.Drug and alcohol dependence · 2019Pooled it
- Reliability of White Matter Microstructural Changes in HIV Infection: Meta-Analysis and Confirmation.AJNR. American journal of neuroradiology · 2017Pooled it
- PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial.Addiction (Abingdon, England) · 2017Trial
- Assessing white matter integrity as a function of abstinence duration in former cocaine-dependent individuals.Drug and alcohol dependence · 2011Trial
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum.Brain structure & function · 2023Article
- Strengthened and posterior-shifted structural rich-club organization in people who use cocaine.Drug and alcohol dependence · 2022Article
- The impact of levamisole and alcohol on white matter microstructure in adult chronic cocaine users.Addiction biology · 2022Article
- Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.PloS one · 2021Article
- Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol.Journal of proteome research · 2019Article
- Regional elevations in microglial activation and cerebral glucose utilization in frontal white matter tracts of rhesus monkeys following prolonged cocaine self-administration.Brain structure & function · 2019Article
- Selective micro-structural integrity impairment of the isthmus subregion of the corpus callosum in alcohol-dependent males.BMC psychiatry · 2019Article
- PPARγ agonism attenuates cocaine cue reactivity.Addiction biology · 2018Article
- Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection.Journal of neurovirology · 2017Article
- A preliminary longitudinal study of white matter alteration in cocaine use disorder subjects.Drug and alcohol dependence · 2017Article
- Shared microstructural features of behavioral and substance addictions revealed in areas of crossing fibers.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Larger corpus callosum and reduced orbitofrontal cortex homotopic connectivity in codeine cough syrup-dependent male adolescents and young adults.European radiology · 2017Article
- White Matter Integrity Deficit Associated with Betel Quid Dependence.Frontiers in psychiatry · 2017Article
- The effects of oral d-amphetamine on impulsivity in smoked and intranasal cocaine users.Drug and alcohol dependence · 2016Article
- INTEGRATIVE BAYESIAN ANALYSIS OF NEUROIMAGING-GENETIC DATA THROUGH HIERARCHICAL DIMENSION REDUCTION.Proceedings. IEEE International Symposium on Biomedical Imaging · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies demonstrated that diffusion tensor imaging (DTI) can provide information regarding white matter integrity of the corpus callosum (CC). In this study, DTI parameters were compared between cocaine dependent subjects (CDs) and non-drug using controls (NCs) in midsagittal CC. DTI images were acquired from 19 CDs and 18 age-matched NCs. The midsagittal CC was segmented into: genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium. Linear mixed models analyses showed that, relative to NCs, CDs had lower fractional anisotropy (FA), higher radial diffusivity (lambda(perpendicular)), and higher mean diffusivity (D(av)) in the isthmus; higher lambda(perpendicular) and D(av) in the rostral body; and lower FA in the splenium. After including mass of lifetime alcohol use in the mixed model analysis of covariance (ANCOVA) as a covariate, significant between group differences in lambda(perpendicular) in the rostral body and isthmus remained. These results suggest that alterations in lambda(perpendicular) in the rostral body and isthmus were mainly due to cocaine use, consistent with previous studies showing that cocaine may alter myelin integrity. Between group differences in FA in the isthmus and splenium, and D(av) in the rostral body and isthmus became non-significant after inclusion of alcohol use as a covariate. This is suggestive of alcohol influencing these values, or may be related to the decreased degrees of freedom for these effects. Consistent with clinical data of greater severity of drug use in smoked versus intranasal cocaine, subjects who smoked cocaine showed lower FA and higher lambda(perpendicular) compared to intranasal CDs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.