ArticleLung cancer (Amsterdam, Netherlands)2010
Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.
Article in Lung cancer (Amsterdam, Netherlands), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Ginger-Derived Exosome-Like Nanoparticles: The Effect of Extraction Methods on Metabolites and in vitro Anti-Lung Cancer Activity.International journal of nanomedicine · 2025Article
- Prostaglandin Reductase 1 as a Potential Therapeutic Target for Cancer Therapy.Frontiers in pharmacology · 2021Review
- MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role.Aging · 2020Article
- Skeletal muscle proteome analysis provides insights on high altitude adaptation of yaks.Molecular biology reports · 2019Article
- Article
- Hepatic transcriptomic alterations for N,N-dimethyl-p-toluidine (DMPT) and p-toluidine after 5-day exposure in rats.Archives of toxicology · 2017Article
- High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex.BioMed research international · 2016Article
- Effect of prostaglandin reductase 1 (PTGR1) on gastric carcinoma using lentivirus-mediated system.International journal of clinical and experimental pathology · 2015Article
- Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase?Oxidative medicine and cellular longevity · 2015Article
- Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity.Journal of lipid research · 2013Article
- An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Leukotriene B(4)-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase (LTBDH/PGR) is a bifunctional enzyme capable of inactivating leukotriene B(4) (LTB(4)) and 15-oxo-prostaglandins (15-PGs). Its role in growth suppressive functions in lung cancer was studied in in vitro and in vivo systems. The LTBDH/PGR gene was expressed in lung cancer cell lines through recombinant adenovirus infection, and through a tetracycline-inducible expression system. After restoration of LTBDH/PGR expression in LTBDH/PGR-negative (H1299) or -low (A549) lung cancer cell lines, the restored enzyme induced apoptosis and growth inhibition in vitro. Ectopic expression of LTBDH/PGR caused also suppression of tumorigenicity of A549 cells in nude mice. In contrast, LTBDH/PGR over-expression in LTBDH/PGR-positive (H157) lung cancer cell line induced little apoptosis and growth inhibition. This study indicates that restoration of LTBDH/PGR expression is effective in preventing lung cancer growth in vitro and in vivo.
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