ArticleGenome biology2009
Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals.
Article in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
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- Human Single-Cell RNA-Sequencing Data Supports the Hypothesis of X Chromosome Insensitivity but Is Ineffective in Testing the Dosage Compensation Model.Molecular biology and evolution · 2025Article
- Co-expression Networks From Gene Expression Variability Between Genetically Identical Seedlings Can Reveal Novel Regulatory Relationships.Frontiers in plant science · 2020Article
- Article
- Widespread inter-individual gene expression variability inMolecular systems biology · 2019Article
- Dosage sensitivity of X-linked genes in human embryonic single cells.BMC genomics · 2019Article
- Dosage-Dependent Expression Variation Suppressed on theG3 (Bethesda, Md.) · 2018Article
- Aberrant expression of miR-153 is associated with overexpression of hypoxia-inducible factor-1α in refractory epilepsy.Scientific reports · 2016Article
- Rapamycin inhibited the function of lung CSCs via SOX2.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation.PLoS genetics · 2015Article
- Increased expression of X-linked genes in mammals is associated with a higher stability of transcripts and an increased ribosome density.Genome biology and evolution · 2015Article
- Macrophage infiltration promotes invasiveness of breast cancer cells via activating long non-coding RNA UCA1.International journal of clinical and experimental pathology · 2015Article
- TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185.International journal of clinical and experimental pathology · 2015Article
- Enhanced expression of stem cell markers and drug resistance in sphere-forming non-small cell lung cancer cells.International journal of clinical and experimental pathology · 2015Article
- The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Association between plasma homocysteine and progression of early nephropathy in type 2 diabetic patients.International journal of clinical and experimental medicine · 2015Article
- DNA methylation and transcriptional noise.Epigenetics & chromatin · 2013Article
- Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity.Heredity · 2012Article
- Dosage compensation of the sex chromosomes.Annual review of genetics · 2012Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTheory predicts that haploid-expressed genes should have noisier expression than comparable diploid-expressed ones with the same expression level. However, in mammals there are several classes of gene that are monoallelically expressed, including X-linked genes, imprinted genes and some other autosomal genes. Does it follow that the evolution of X chromosomes in eukaryotes comes at the cost of increased transcriptional noise in the heterogametic sex? Moreover, is escaping X-inactivation in mammalian females associated with an increase in transcriptional variation? To address these questions, we analyze gene expression variation between replicate samples of diverse mammalian cell lines in steady-state using microarray data.
resultsWe observe that transcriptional variation of X-linked genes is no different to that of autosomal genes both before and after control for transcript abundance. By contrast, autosomal genes subject to allelic exclusion do have unusually high noise levels even allowing for their low transcript abundance. The prior theory we suggest was insufficient, at least as regards X-chromosomes, as it failed to appreciate the regulatory complexity of gene expression, not least the effects of genomic neighborhood.
conclusionsThese results suggest that high noise is not a necessary consequence of haploid expression and emphasize the primacy of expression level as a determinant of noise. The latter has consequences for understanding the etiology of haplo-insufficiency and the evolution of gene expression levels. Given the coupling between expression level and noise on the X-chromosome, we suggest that part of the selective advantage of dosage compensation is noise abatement of X-linked genes.
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