ArticleThe Plant journal : for cell and molecular biology2009
Phytoene synthase activity controls the biosynthesis of carotenoids and the supply of their metabolic precursors in dark-grown Arabidopsis seedlings.
Article in The Plant journal : for cell and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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117 citing papers in PubMed.
- Turning over a green leaf: integrating light signals toward chloroplast establishment.Plant physiology · 2026Review
- A Novel Dual-Target Compound Designed With Potent Herbicidal and Fungicidal Activity Inspired by Conserved Phytoene Synthase Domains.Plant biotechnology journal · 2026Article
- Suppression of microRNAs targeting key MEP pathway genes affects plastid terpenoid content and photosynthesis under variable light conditions.Molecular biology reports · 2026Article
- Genotype × environment interactions underlying geographic divergence in carotenoid accumulation and kernel pigmentation of foxtail millet.BMC plant biology · 2026Article
- Diversification of tobacco phytoene-synthase-encoding genes coordinates carotenoid flux, strigolactone biosynthesis, and cold responses.Frontiers in plant science · 2026Article
- Assembling the chromosome-level genome of Arctium Lappa L. provides new insights into carotenoid biosynthesis.BMC plant biology · 2025Article
- Light-Quality-Dependent Greening and Steroidal Glycoalkaloid Accumulation in Potato Tubers: Regulatory Mechanisms and Postharvest Strategies to Reduce Food Safety Risks.Foods (Basel, Switzerland) · 2025Article
- Effect of Fluridone on Roots and Leaf Buds Development in Stem Cuttings ofMolecules (Basel, Switzerland) · 2024Article
- Exogenous application of the apocarotenoid retinaldehyde negatively regulates auxin-mediated root growth.Plant physiology · 2024Article
- Albino lethal 13, a chloroplast-imported protein required for chloroplast development in rice.Plant direct · 2024Article
- Nudix hydrolase 23 post-translationally regulates carotenoid biosynthesis in plants.The Plant cell · 2024Article
- Arabidopsis FIBRILLIN6 influences carotenoid biosynthesis by directly promoting phytoene synthase activity.Plant physiology · 2024Article
- 15-Foods (Basel, Switzerland) · 2024Article
- Plant competition cues activate a singlet oxygen signaling pathway inFrontiers in plant science · 2024Article
- Transcriptome Profiling Provides Insights into the Early Development of Tiller Buds in High- and Low-Tillering Orchardgrass Genotypes.International journal of molecular sciences · 2023Article
- Comparative Analysis of Carotenoid Profiles and Biosynthetic Gene Expressions among Ten Plum Cultivars.Plants (Basel, Switzerland) · 2023Article
- Genetic and molecular basis of carotenoid metabolism in cereals.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Review
- ImprovingGenes · 2023Article
- Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin (Journal of Zhejiang University. Science. B · 2023Article
- Bioactive compounds by microalgae and potentials for the management of some human disease conditions.AIMS microbiology · 2023Review
57 more citing papers are in PubMed but not listed here.
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Abstract
Carotenoids are plastidial isoprenoids essential for plant life. In Arabidopsis thaliana carotenoid biosynthesis is strongly upregulated when seedlings that germinate in the dark (etiolated) emerge from the soil and light derepresses photomorphogenesis, causing etioplasts to become chloroplasts. We found that carotenoid biosynthesis is also induced when deetiolation is derepressed in the absence of actual light, eventually resulting in improved greening (chlorophyll accumulation) upon illumination. The increased production of carotenoids in the dark correlates with an upregulated activity of phytoene synthase (PSY; the first committed enzyme of carotenogenesis) and the induction of PSY gene expression in cotyledons (where carotenoids accumulate in dark-grown seedlings). The metabolic precursors for carotenoid synthesis under these conditions are mostly supplied by the plastidial methylerythritol 4-phosphate (MEP) pathway. Accumulation of flux-controlling MEP pathway enzymes, such as deoxyxylulose 5-phosphate synthase (DXS), is post-transcriptionally increased when deetiolation is derepressed in the dark. Unlike the situation observed in light-grown plants, however, the sole overexpression of DXS in dark-grown seedlings does not increase carotenoid accumulation. By contrast, induced expression of a PSY-encoding transgene results in increased carotenoid levels and a concomitant post-transcriptional accumulation of DXS. These data provide evidence for a feedback mechanism by which PSY controls metabolic flux to the carotenoid pathway in plants.
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