ArticleAging cell2009
d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila.
Article in Aging cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- 4E-BP inhibition ameliorates heart failure through translational upregulation of SERCA2a and modulation of mitochondrial redox signaling in cardiomyocytes.Redox biology · 2026Article
- Fine-tuning striated muscle performance: conserved sarcomere-level mechanisms across insect and vertebrate systems.Frontiers in physiology · 2026Review
- Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging.GeroScience · 2025Article
- Animal models in biomedical research: Relevance ofHeliyon · 2025Review
- Molecular mechanism on autophagy associated cardiovascular dysfunction inFrontiers in cell and developmental biology · 2025Review
- Selection for greater dispersal in early life increases rate of age-dependent decline in locomotor activity and shortens lifespan.Journal of evolutionary biology · 2024Article
- Protein translation paradox: Implications in translational regulation of aging.Frontiers in cell and developmental biology · 2023Review
- The opportunities and challenges of usingFrontiers in physiology · 2023Article
- The mTOR signaling pathway in cardiac aging.The journal of cardiovascular aging · 2023Article
- Exercise Training Upregulates CardiacBiology · 2022Article
- Molecular inhibition of RAS signalling to target ageing and age-related health.Disease models & mechanisms · 2022Review
- Contributive Role of Hyperglycemia and Hypoglycemia Towards the Development of Alzheimer's Disease.Molecular neurobiology · 2022Review
- Phenotyping ofBiomolecules · 2022Review
- Article
- Review
- Physical exercise prevents age-related heart dysfunction induced by high-salt intake and heartAging · 2021Article
- TOR Signaling Pathway in Cardiac Aging and Heart Failure.Biomolecules · 2021Review
- Cardiac Aging: From Basic Research to Therapeutics.Oxidative medicine and cellular longevity · 2021Review
- TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.Autophagy · 2020Article
- Non-invasive red-light optogenetic control of Drosophila cardiac function.Communications biology · 2020Article
Corrections and comments
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Authors and funding
11 authors.
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Abstract
dTOR (target of rapamycin) and dFoxo respond to changes in the nutritional environment to induce a broad range of responses in multiple tissue types. Both dTOR and dFoxo have been demonstrated to control the rate of age-related decline in cardiac function. Here, we show that the Eif4e-binding protein (d4eBP) is sufficient to protect long-term cardiac function against age-related decline and that up-regulation of dEif4e is sufficient to recapitulate the effects of high dTOR or insulin signaling. We also provide evidence that d4eBP acts tissue-autonomously and downstream of dTOR and dFoxo in the myocardium, where it enhances cardiac stress resistance and maintains normal heart rate and myogenic rhythm. Another effector of dTOR and insulin signaling, dS6K, may influence cardiac aging nonautonomously through its activity in the insulin-producing cells, possibly by regulating dilp2 expression. Thus, elevating d4eBP activity in cardiac tissue represents an effective organ-specific means for slowing or reversing cardiac functional changes brought about by normal aging.
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Registered trials
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