ArticleJournal of neurotrauma2009
Monitoring hippocampus electrical activity in vitro on an elastically deformable microelectrode array.
Article in Journal of neurotrauma, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 73 citations in OpenAlex.
- Long-term potentiation and long-term depression are both impaired afterBiomedical physics & engineering express · 2025Article
- Stretch-Induced Injury Affects Cortical Neuronal Networks in a Time- and Severity-Dependent Manner.Annals of biomedical engineering · 2024Article
- Architecture design and advanced manufacturing of heart-on-a-chip: scaffolds, stimulation and sensors.Microsystems & nanoengineering · 2024Review
- Innovations in 3-Dimensional Tissue Models of Human Brain Physiology and Diseases.Advanced functional materials · 2020Article
- Organotypic Hippocampal Slices as Models for Stroke and Traumatic Brain Injury.Molecular neurobiology · 2016Review
- Nano-Bioelectronics.Chemical reviews · 2016Review
- Alterations in Hippocampal Network Activity after In Vitro Traumatic Brain Injury.Journal of neurotrauma · 2015Article
- The mechanics of traumatic brain injury: a review of what we know and what we need to know for reducing its societal burden.Journal of biomechanical engineering · 2014Review
- Nanoelectronics meets biology: from new nanoscale devices for live-cell recording to 3D innervated tissues.Chemistry, an Asian journal · 2013Review
- Nanoelectronics-biology frontier: From nanoscopic probes for action potential recording in live cells to three-dimensional cyborg tissues.Nano today · 2013Article
- An organotypic uniaxial strain model using microfluidics.Lab on a chip · 2013Article
- Size-Dependent Rupture Strain of Elastically Stretchable Metal Conductors.Scripta materialia · 2012Article
- Encapsulating Elastically Stretchable Neural Interfaces: Yield, Resolution, and Recording/Stimulation of Neural Activity.Advanced functional materials · 2012Article
- Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo.Nature neuroscience · 2011Article
- Biomechanics of concussion.Clinics in sports medicine · 2011Review
- Flexible and stretchable micro-electrodes for in vitro and in vivo neural interfaces.Medical & biological engineering & computing · 2010Review
- Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.Nature materials · 2010Article
- Experimental mild traumatic brain injury induces functional alteration of the developing hippocampus.Journal of neurophysiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Interfacing electronics and recording electrophysiological activity in mechanically active biological tissues is challenging. This challenge extends to recording neural function of brain tissue in the setting of traumatic brain injury (TBI), which is caused by rapid (within hundreds of milliseconds) and large (greater than 5% strain) brain deformation. Interfacing electrodes must be biocompatible on multiple levels and should deform with the tissue to prevent additional mechanical damage. We describe an elastically stretchable microelectrode array (SMEA) that is capable of undergoing large, biaxial, 2-D stretch while remaining functional. The new SMEA consists of elastically stretchable thin metal films on a silicone membrane. It can stimulate and detect electrical activity from cultured brain tissue (hippocampal slices), before, during, and after large biaxial deformation. We have incorporated the SMEA into a well-characterized in vitro TBI research platform, which reproduces the biomechanics of TBI by stretching the SMEA and the adherent brain slice culture. Mechanical injury parameters, such as strain and strain rate, can be precisely controlled to generate specific levels of damage. The SMEA allowed for quantification of neuronal function both before and after injury, without breaking culture sterility or repositioning the electrodes for the injury event, thus enabling serial and long-term measurements. We report tests of the SMEA and an initial application to study the effect of mechanical stimuli on neuron function, which could be employed as a high-content, drug-screening platform for TBI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.