ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2010
Gene expression profiling in monocytes and SNP association suggest the importance of the STAT1 gene for osteoporosis in both Chinese and Caucasians.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- P4 medicine and osteoporosis: a systematic review.Wiener klinische Wochenschrift · 2016Pooled it
- Attenuated monocyte apoptosis, a new mechanism for osteoporosis suggested by a transcriptome-wide expression study of monocytes.PloS one · 2015Trial
- An atlas of genetic effects on the monocyte methylome across European and African populations.Genome medicine · 2026Article
- A Machine Learning Framework for Screening Plasma Cell-Associated Feature Genes to Estimate Osteoporosis Risk and Treatment Vulnerability.Biochemical genetics · 2025Article
- The Association ofBiomolecules · 2025Article
- Identifying a causal link between prolactin signaling pathways and COVID-19 vaccine-induced menstrual changes.NPJ vaccines · 2023Article
- Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study.Scientific reports · 2021Article
- Immunoporosis: Role of Innate Immune Cells in Osteoporosis.Frontiers in immunology · 2021Review
- Do We Use Methylation ofBalkan journal of medical genetics : BJMG · 2020Article
- A correlative studies between osteoporosis and blood cell composition: Implications for auxiliary diagnosis of osteoporosis.Medicine · 2020Article
- A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia.Clinical and translational medicine · 2020Article
- Gene-based GWAS analysis for consecutive studies of GEFOS.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- EPS-LASSO: test for high-dimensional regression under extreme phenotype sampling of continuous traits.Bioinformatics (Oxford, England) · 2018Article
- Alendronate promotes osteoblast differentiation and bone formation in ovariectomy-induced osteoporosis through interferon-β/signal transducer and activator of transcription 1 pathway.Experimental and therapeutic medicine · 2018Article
- "Omics" Signatures in Peripheral Monocytes from Women with Low BMD Condition.Journal of osteoporosis · 2018Review
- The Role of Monocyte Percentage in Osteoporosis in Male Rheumatic Diseases.American journal of men's health · 2017Article
- Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- CC chemokines CCL2, CCL3, CCL4 and CCL5 are elevated in osteoporosis patients.Journal of biomedical research · 2017Article
- Circulating monocytes: an appropriate model for bone-related study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Review
- Signaling pathway STAT1 is strongly activated by IFN-β in the pathogenesis of osteoporosis.European journal of medical research · 2015Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Osteoporosis is characterized mainly by low bone mineral density (BMD). Many cytokines and chemokines have been related with bone metabolism. Monocytes in the immune system are important sources of cytokines and chemokines for bone metabolism. However, no study has investigated in vivo expression of a large number of various factors simultaneously in human monocytes underlying osteoporosis. This study explored the in vivo expression pattern of general cytokines, chemokines, and their receptor genes in human monocytes and validated the significant genes by qRT-PCR and genetic association analyses. Expression profilings were performed in monocyte samples from 26 Chinese and 20 Caucasian premenopausal women with discordant BMD. Genome-wide association analysis with BMD variation was conducted in 1000 unrelated Caucasians. We selected 168 cytokines, chemokines, osteoclast-related factors, and their receptor genes for analyses. Significantly, the signal transducer and activator of transcription 1 (STAT1) gene was upregulated in the low versus the high BMD groups in both Chinese and Caucasians. We also revealed a significant association of the STAT1 gene with BMD variation in the 1000 Caucasians. Thus we conclude that the STAT1 gene is important in human circulating monocytes in the etiology of osteoporosis.
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Registered trials
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