ArticleCNS drugs2009
Patients' attitudes towards generic substitution of oral atypical antipsychotics: a questionnaire-based survey in a hypothetical pharmacy setting.
Article in CNS drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- What Do Users of Generic Medicines Think of Them? A Systematic Review of Consumers' and Patients' Perceptions of, and Experiences with, Generic Medicines.The patient · 2016Pooled it
- What do people really think of generic medicines? A systematic review and critical appraisal of literature on stakeholder perceptions of generic drugs.BMC medicine · 2015Pooled it
- Cardiovascular risk management in patients using antipsychotics: a qualitative feasibility study.BJGP open · 2026Article
- Uncovering patients' preferences for brand among essential classes of coronary heart disease medications using a discrete choice experiment.Scientific reports · 2024Article
- Generic substitution of epinephrine autoinjectors: Patient and caregiver perceptions and attitudes.The journal of allergy and clinical immunology. Global · 2024Article
- Analysis of the Korean generic medicine market: Factors affecting the market share of generic medicines.Clinical and translational science · 2022Article
- Patient Perceptions of Switching to a Generic Dry Powder Inhaler - Increased Understanding Through Journey Mapping.International journal of chronic obstructive pulmonary disease · 2022Article
- Utilization of Generic Cardiovascular Drugs in Medicare's Part D Program.Circulation. Cardiovascular quality and outcomes · 2021Article
- The Use of Generic Medications for Glaucoma.Journal of ophthalmology · 2020Review
- Potential Clinical and Economic Impact of Switching Branded Medications to Generics.American journal of therapeutics · 2017Review
- Article
- Variations in Patients' Perceptions and Use of Generic Drugs: Results of a National Survey.Journal of general internal medicine · 2016Article
- The introduction of generic risperidone in Medicare Part D.The American journal of managed care · 2016Article
- Pharmacy switch of antipsychotic medications: patient's perspective.Annals of general psychiatry · 2015Article
- [Risk factors for treatment adherence in patients with schizophrenia: case-control study].The Pan African medical journal · 2015Article
- Patient perceptions of generic medicines: a mixed-methods study.The patient · 2014Article
- Rational use of generic psychotropic drugs.CNS drugs · 2013Review
- Switching from brand-name to generic psychotropic medications: a literature review.CNS neuroscience & therapeutics · 2011Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGeneric atypical antipsychotics in tablet form differ in name, appearance and packaging from the innovator brand antipsychotics. These differences might cause anxiety, confusion and misperceptions in some ambulant patients with psychoses/schizophrenia, especially if the brand atypical antipsychotic is substituted in the pharmacy without the acknowledgement of the patient and treating psychiatrist. Furthermore, generic substitution of branded oral atypical antipsychotics in the pharmacy might cause nonadherence and potentially lead to suboptimal treatment outcomes if patients perceive the medicines to be clinically different.
objectiveTo determine the attitudes of patients with psychoses/schizophrenia towards generic substitution of oral atypical antipsychotics in a pharmacy setting.
methodsA total of 106 ambulant patients with psychoses/schizophrenia currently taking an oral atypical antipsychotic (risperidone [Risperdal], olanzapine [Zyprexa], quetiapine [Seroquel] or aripiprazole [Abilify]) were confronted with generic substitution in a hypothetical pharmacy setting.Two conditions were used: one granting patients a short explanation about the substitution, and one without explanation. Patients' attitudes towards the generic substitution were assessed using a combined quantitative and qualitative design.
resultsOf the respondents, 73% stated that they would be unlikely to take a generic antipsychotic if their pharmacist were to substitute it. Providing patients with a short explanation had a significantly positive effect on their intention to take a generic version; however, overall, the patients' intention to take the generic antipsychotic lay well below a neutral midpoint.
conclusionPatients with psychoses/schizophrenia using atypical antipsychotics in tablet form perceive generic versions of their antipsychotics as being significantly different. This perceived difference lowers their intention of continuing to take the medication, thus possibly jeopardizing treatment outcome. Caution with the generic substitution of atypical antipsychotics in the pharmacy is therefore recommended. Generic substitution should take place only with the knowledge and agreement of the psychiatrist and the patient.
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Registered trials
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