ArticleBiochemistry2009
Wasp mastoparans follow the same mechanism as the cell-penetrating peptide transportan 10.
Article in Biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Growth ofbioRxiv : the preprint server for biology · 2024Article
- Cell-Penetrating Peptides and Transportan.Pharmaceutics · 2021Review
- Review
- Mechanistic Landscape of Membrane-Permeabilizing Peptides.Chemical reviews · 2019Review
- Daptomycin-Phosphatidylglycerol Domains in Lipid Membranes.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Lipid-packing perturbation of model membranes by pH-responsive antimicrobial peptides.Biophysical reviews · 2017Review
- Charged Antimicrobial Peptides Can Translocate across Membranes without Forming Channel-like Pores.Biophysical journal · 2017Article
- Pro-apoptotic Bax molecules densely populate the edges of membrane pores.Scientific reports · 2016Article
- Membrane-active peptides: binding, translocation, and flux in lipid vesicles.Biochimica et biophysica acta · 2014Review
- Effect of the aspartic acid D2 on the affinity of Polybia-MP1 to anionic lipid vesicles.European biophysics journal : EBJ · 2014Article
- A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses.Peptides · 2013Article
- In vitro activity of telavancin in combination with colistin versus Gram-negative bacterial pathogens.Antimicrobial agents and chemotherapy · 2012Article
- What determines the activity of antimicrobial and cytolytic peptides in model membranes.Biochemistry · 2011Article
- A thermodynamic approach to the mechanism of cell-penetrating peptides in model membranes.Biochemistry · 2011Article
- Fluctuations and the rate-limiting step of peptide-induced membrane leakage.Biophysical journal · 2010Article
- Diffusion as a probe of the heterogeneity of antimicrobial peptide-membrane interactions.Biochemistry · 2010Article
- Mechanisms of antimicrobial, cytolytic, and cell-penetrating peptides: from kinetics to thermodynamics.Biochemistry · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have been examining the mechanism and kinetics of the interactions of a selected set of peptides with phospholipid membranes in a quantitative manner. This set was chosen to cover a broad range of physical-chemical properties and cell specificities. Mastoparan (masL) and mastoparan X (masX) are two similar peptides from the venoms of the wasps Vespula lewisii and Vespa xanthoptera, respectively, and were chosen to complete the set. The rate constants for masX association with and dissociation from membranes are reported here for the first time. The kinetics of dye efflux induced by both mastoparans from phospholipid vesicles were also examined and quantitatively analyzed. We find that masL and masX follow the same graded kinetic model that we previously proposed for the cell-penetrating peptide transportan 10 (tp10), but with different parameters. This comparison is relevant because tp10 is derived from masL by addition of a mostly nonpolar segment of seven residues at the N-terminus. Tp10 is more active than the mastoparans toward phosphatidylcholine vesicles, but the mastoparans are more sensitive to the effect of anionic lipids. Furthermore, the Gibbs free energies of binding and insertion of the peptides calculated using the Wimley-White transfer scales are in good agreement with the values derived from our experimental data and are useful for understanding peptide behavior.
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