Evidence map›Paper›PMID 19593916›Full record

ArticleNeuroreport2009

Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice.

Carolyn J Koonce, Alicia A Walf, Cheryl A Frye

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroreport, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Carolyn J KoonceDepartment of aPsychology, University at Albany-SUNY, Albany, New York 12222, USA.
Alicia A Walf
Cheryl A Frye
University at Albany, State University of New York · US

Funding

Progestogens' non-classical effects and mechanisms for social & mood processesR01MH067698 · NIMH · UNIVERSITY OF ALASKA FAIRBANKS · PI DREW, KELLY L · 2004 to 2013
$2.4M
Progestins' non-genomic actions for socio-sexual behaviorR56MH067698 · NIMH · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI FRYE, CHERYL ANNE · 2009 to 2009
$379k
NIMH NIH HHS MH06769801NIMH NIH HHS R01 MH067698NIMH NIH HHS R56 MH067698
6 · The paper itself

Abstract

Women with estrogen receptor (ER) positive breast cancer, who are treated with the ER blocker, tamoxifen, have an increased risk of depression. Trilostane, a 3b-hydroxysteroid dehydrogenase inhibitor, is now being used to treat tamoxifen-insensitive breast cancer. In-vitro assays show that trilostane may have actions through ERb. Results of in-vivo research shows that actions at ERb may underline some antidepressant effects of estrogen. We hypothesized that trilostane may exert antidepressive effects in the forced swim in part due to actions through ERb. Trilostane (25 mg/kg, intraperitoneally), compared with vehicle, had significant antidepressant-like effects but only when administered to wild-type, not ERb knockout, mice. Thus, actions of trilostane through ERb may underlie some of its antidepressant-like effects.

Indexed as

Analysis of VarianceAnimalsAntidepressive AgentsCorticosteroneDepressionDihydrotestosteroneEstrogen Receptor betaHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutMotor ActivityNeuropsychological TestsPregnanoloneRadioimmunoassayAntidepressive AgentsCorticosteroneDihydrotestosteroneEstrogen Receptor betaPregnanolonetrilostane

Identifiers

PMID19593916
PMCPMC3623943
OpenAlexW2057311244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.