ArticleCell motility and the cytoskeleton2009
Profilin-1 overexpression restores adherens junctions in MDA-MB-231 breast cancer cells in R-cadherin-dependent manner.
Article in Cell motility and the cytoskeleton, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- SerFrontiers in cell and developmental biology · 2021Article
- Endometrial profilin 1: a key player in embryo-endometrial crosstalk.Clinical and experimental reproductive medicine · 2020Article
- Serine protease modulation of Dependence Receptors and EMT protein expression.Cancer biology & therapy · 2019Article
- A balanced level of profilin-1 promotes stemness and tumor-initiating potential of breast cancer cells.Cell cycle (Georgetown, Tex.) · 2017Article
- Article
- Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation.Cell cycle (Georgetown, Tex.) · 2015Article
- Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis.Oncogene · 2014Article
- Actin filaments at the leading edge of cancer cells are characterized by a high mobile fraction and turnover regulation by profilin I.PloS one · 2014Article
- Article
- Quantitative proteomic analysis in metastatic renal cell carcinoma reveals a unique set of proteins with potential prognostic significance.Molecular & cellular proteomics : MCP · 2013Article
- Profilin 1 is a potential biomarker for bladder cancer aggressiveness.Molecular & cellular proteomics : MCP · 2012Article
- Using proteomic approach to identify tumor-associated proteins as biomarkers in human esophageal squamous cell carcinoma.Journal of proteome research · 2011Article
- ODAM Expression Inhibits Human Breast Cancer Tumorigenesis.Breast cancer : basic and clinical research · 2011Article
- Article
- Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation.Journal of cellular physiology · 2010Article
- Role of the actin-binding protein profilin1 in radial migration and glial cell adhesion of granule neurons in the cerebellum.Cell adhesion & migrationArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Profilin-1 (Pfn1), a ubiquitously expressed actin-binding protein, is downregulated in several different types of adenocarcinoma and elicits tumor-suppressive effect on breast cancer cell lines. MDA-MB-231 (MDA-231), a breast cancer cell line that displays all the characteristics of post-epithelial-to-mesenchymal transition and does not form cell-cell adhesion, can be reverted to an epithelioid phenotype by Pfn1 overexpression. This morphological transition is caused by restoration of adherens junctions (AJ) requiring Pfn1's interaction with actin. Pfn1 overexpression increases the expression level of R-cadherin (a type of cadherin that is endogenously expressed in the parental cell line) and restores AJ in MDA-231 cells in R-cadherin-dependent manner. These findings highlight important role of Pfn1 in the regulation of epithelial cell-cell adhesion.
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