ArticleEuropean journal of nuclear medicine and molecular imaging2009
Cardiovascular events in Japanese asymptomatic patients with type 2 diabetes: a 1-year interim report of a J-ACCESS 2 investigation using myocardial perfusion imaging.
Article in European journal of nuclear medicine and molecular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017.Journal of atherosclerosis and thrombosis · 2018Guideline
- Using Multivariate Adaptive Regression Splines to Estimate Summed Stress Score on Myocardial Perfusion Scintigraphy in Chinese Women with Type 2 Diabetes: A Comparative Study with Multiple Linear Regression.Diagnostics (Basel, Switzerland) · 2025Article
- A novel algorithm developed using machine learning and a J-ACCESS database can estimate defect scores from myocardial perfusion single-photon emission tomography images.Annals of nuclear medicine · 2024Article
- Comparison between multiple logistic regression and machine learning methods in prediction of abnormal thallium scans in type 2 diabetes.World journal of clinical cases · 2023Article
- Comparison between Machine Learning and Multiple Linear Regression to Identify Abnormal Thallium Myocardial Perfusion Scan in Chinese Type 2 Diabetes.Diagnostics (Basel, Switzerland) · 2022Article
- Predictors of abnormality in thallium myocardial perfusion scans for type 2 diabetes.Heart and vessels · 2021Article
- The First Harmonic of Radial Pulse as an Early Predictor of Silent Coronary Artery Disease and Adverse Cardiac Events in Type 2 Diabetic Patients.Cardiology research and practice · 2018Article
- Prevalence and predictors of ischemia and outcomes in outpatients with diabetes mellitus referred for single-photon emission computed tomography myocardial perfusion imaging.Circulation. Cardiovascular imaging · 2013Article
- Microalbuminuria predicts silent myocardial ischaemia in type 2 diabetes patients.European journal of nuclear medicine and molecular imaging · 2013Article
- Metabolic syndrome is not a predictor for cardiovascular events in Japanese patients with diabetes mellitus asymptomatic for coronary artery disease: a retrospective analysis of the J-ACCESS-2 study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Prognostic value of gated myocardial perfusion imaging for asymptomatic patients with type 2 diabetes: the J-ACCESS 2 investigation.Diabetes care · 2010Article
- Clinical use of nuclear cardiology in the assessment of heart failure.World journal of cardiology · 2010Article
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9 authors at 9 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeDiabetic patients have a high risk for cardiovascular events. The role of myocardial perfusion imaging was investigated in asymptomatic diabetic patients to evaluate short-term prognosis in a Japanese population.
methodsA total of 506 asymptomatic patients ≥ 50 years of age who had carotid artery maximum intima-media thickness ≥ 1.1 mm, urinary albumin excretion of ≥ 30 mg/g creatinine, with additional criteria of abdominal obesity, low HDL cholesterol, high triglyceride level, and hypertension were enrolled and followed up over a 3-year period. Gated SPECT with stress-rest protocol was performed and analyzed by summed defect scores and QGS software. One-year cardiovascular events were analyzed.
resultsMyocardial ischemia was observed in 17% of patients, and abnormal perfusion findings of ischemia and/or scar were observed in 32% of patients. By the end of the 1-year follow-up, 33 (6.5%) cardiovascular events occurred including 6 all-cause deaths. Patients with summed stress score (SSS) >8 had a higher incidence of either death or cardiovascular events. Event-free survival rates for SSS 0-3, 4-8, 9-13, and ≥ 14 were 0.96, 0.95, 0.82, and 0.76, respectively. Multivariate Cox regression analysis showed that significant variables were SSS, history of cerebrovascular accident, and electrocardiographic abnormality at rest.
conclusionThe 1-year interim summary showed that cardiovascular events were significantly higher in patients with SPECT abnormality, although hard cardiac event rate was relatively low. Targeted treatment strategy is required for asymptomatic but potentially high-risk diabetic patients.
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