ArticlePloS one2009
Biogeography and virulence of Staphylococcus aureus.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2013Pooled it
- OralPathogens (Basel, Switzerland) · 2024Article
- Comparative analysis of genomic characteristics, virulence and fitness of community-associatedVirulence · 2023Article
- Antibiotic susceptibility and clonal distribution ofFrontiers in cellular and infection microbiology · 2023Article
- Article
- Increasing incidence of bloodstream infections due to Staphylococcus aureus clonal complex 398 in a French hospital between 2010 and 2017.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Comparative Secretome Analyses of Human and ZoonoticMolecular & cellular proteomics : MCP · 2018Article
- Characterization of community-associated Staphylococcus aureus from skin and soft-tissue infections: a multicenter study in China.Emerging microbes & infections · 2016Article
- Molecular typing, virulence traits and antimicrobial resistance of diabetic foot staphylococci.Journal of biomedical science · 2016Article
- Typing of Panton-Valentine Leukocidin-Encoding Phages and lukSF-PV Gene Sequence Variation in Staphylococcus aureus from China.Frontiers in microbiology · 2016Article
- Antibiotics in agriculture and the risk to human health: how worried should we be?Evolutionary applications · 2015Review
- Panton-Valentine leukocidin (PVL)-positive health care-associated methicillin-resistant Staphylococcus aureus isolates are associated with skin and soft tissue infections and colonized mainly by infective PVL-encoding bacteriophages.Journal of clinical microbiology · 2015Article
- Community-associated methicillin-resistant Staphylococcus aureus case studies.Methods in molecular biology (Clifton, N.J.) · 2014Review
- Article
- The genetic structure of Staphylococcus aureus populations from the Southwest Pacific.PloS one · 2014Article
- High prevalence of hospital-associated methicillin-resistant Staphylococcus aureus in the community in Portugal: evidence for the blurring of community-hospital boundaries.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
- Emergence of sequence type 398 as a community- and healthcare-associated methicillin-susceptible staphylococcus aureus in northern Manhattan.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Asymptomatic carriage of sequence type 398, spa type t571 methicillin-susceptible Staphylococcus aureus in an urban jail: a newly emerging, transmissible pathogenic strain.Journal of clinical microbiology · 2013Article
- Article
- Population genetic structures of Staphylococcus aureus isolates from cats and dogs in Japan.Journal of clinical microbiology · 2012Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundStaphylococcus aureus is commonly carried asymptomatically in the human anterior nares and occasionally enters the bloodstream to cause invasive disease. Much of the global diversity of S. aureus remains uncharacterised, and is not clear how disease propensity varies between strains, and between host populations. METHODOLOGY: We compared 147 isolates recovered from five kindergartens in Chengdu, China, with 51 isolates contemporaneously recovered from cases of pediatric infection from the main hospital serving this community. The samples were characterised by MLST, the presence/absence of PVL, and antibiotic resistance profiling. PRINCIPAL
findingsGenotype frequencies within individual kindergartens differ, but the sample recovered from cases of disease shows a general enrichment of certain MLST genotypes and PVL positive isolates. Genotypes under-represented in the disease sample tend to correspond to a single sequence cluster, and this cluster is more common in China than in other parts of the world. CONCLUSIONS/SIGNIFICANCE: Virulence propensity likely reflects a synergy between variation in the core genome (MLST) and accessory genome (PVL). By combining evidence form biogeography and virulence we demonstrate the existence of a "native" clade in West China which has lowered virulence, possibility due to acquired host immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.