Trial reportMolecular medicine (Cambridge, Mass.)
Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes.
Trial report in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers.The Cochrane database of systematic reviews · 2017Pooled it
- Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances.Molecular psychiatry · 2014Trial
- Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion.Addiction (Abingdon, England) · 2013Trial
- Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement.Pharmacogenomics · 2010Trial
- Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.Molecular medicine (Cambridge, Mass.)Trial
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.Molecular medicine (Cambridge, Mass.)Trial
- The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction.Neural plasticity · 2018Review
- Cadherin 13: humanMolecular medicine (Cambridge, Mass.) · 2016Article
- Mouse Model for Protein Tyrosine Phosphatase D (Molecular medicine (Cambridge, Mass.) · 2015Article
- Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes.Annals of the New York Academy of Sciences · 2015Review
- Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.Molecular brain · 2015Article
- Review
- Altered CSMD1 Expression Alters Cocaine-Conditioned Place Preference: Mutual Support for a Complex Locus from Human and Mouse Models.PloS one · 2015Article
- Implications of genome wide association studies for addiction: are our a priori assumptions all wrong?Pharmacology & therapeutics · 2013Review
- Mouse models for studying genetic influences on factors determining smoking cessation success in humans.Annals of the New York Academy of Sciences · 2012Review
- 'Smoking genes': a genetic association study.PloS one · 2011Article
- Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- The impact of smoking in Crohn's disease: no smoke without fire.Frontline gastroenterology · 2010Review
- Are adolescents with ADHD interested in genetic testing for nicotine addiction susceptibility?International journal of environmental research and public health · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The ability to quit smoking successfully displays substantial heritability in classical and molecular genetic studies. Twin studies suggest that some of the genetics for the ability to quit overlap with genetic components of nicotine dependence, but many do not. Genome-wide association (GWA) studies have demonstrated haplotypes that distinguish successful quitters from individuals who were not able to quit smoking in: i) clinical trials that employed nicotine replacement; ii) clinical trials that employed bupropion; and iii) community quitter samples. We now report novel GWA results from participants in a clinical trial that document the efficacy of adjunctive use of denicotinized cigarettes. These results buttress data from our prior GWA studies of smoking cessation. They suggest that ability to change smoking behavior using denicotinized cigarettes shares substantial underlying genetics with the ability to change this behavior in community settings or in response to treatments with nicotine replacement or bupropion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.