ArticleGeneral physiology and biophysics2009
Effects of cholesterol and unsaturated DOPC lipid on chain packing of saturated gel-phase DPPC bilayers.
Article in General physiology and biophysics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 120 citations in OpenAlex.
- Temperature dependence of membrane viscosity of ternary lipid GUV with LBiophysical journal · 2025Article
- Crystallization ofThe journal of physical chemistry. B · 2025Article
- Do Nanodisc Assembly Conditions Affect Natural Lipid Uptake?Journal of the American Society for Mass Spectrometry · 2023Article
- Viscosity-Sensitive Membrane Dyes as Tools To Estimate the Crystalline Structure of Lipid Bilayers.Analytical chemistry · 2023Article
- Visualizing lipid membrane structure with cryo-EM: past, present, and future.Emerging topics in life sciences · 2023Review
- Article
- A genetically targeted sensor reveals spatial and temporal dynamics of acrosomal calcium and sperm acrosome exocytosis.The Journal of biological chemistry · 2022Article
- Peptide-Folding Triggered Phase Separation and Lipid Membrane Destabilization in Cholesterol-Rich Lipid Vesicles.Bioconjugate chemistry · 2022Article
- The Two Faces of the Liquid Ordered Phase.The journal of physical chemistry letters · 2022Article
- Multiscale compression-induced restructuring of stacked lipid bilayers: From buckling delamination to molecular packing.PloS one · 2022Article
- Partitioning of a Hybrid Lipid in Domains of Saturated and Unsaturated Lipids in a Model Cellular Membrane.ACS omega · 2021Article
- Suppression of LBiophysical journal · 2021Article
- Membrane Adhesion via Glycolipids Occurs for Abundant Saccharide Chemistries.Biophysical journal · 2020Article
- Interleaflet coupling of n-alkane incorporated bilayers.Physical chemistry chemical physics : PCCP · 2020Article
- Polar Interactions Play an Important Role in the Energetics of the Main Phase Transition of Phosphatidylcholine Membranes.ACS omega · 2019Article
- The LLangmuir : the ACS journal of surfaces and colloids · 2018Article
- Phospholipid-mediated exfoliation as a facile preparation method for graphene suspensions.RSC advances · 2018Article
- The Chemical Potential of Plasma Membrane Cholesterol: Implications for Cell Biology.Biophysical journal · 2018Article
- Three-Dimensional Microphase Separation and Synergistic Permeability in Stacked Lipid-Polymer Hybrid Membranes.Chemistry of materials : a publication of the American Chemical Society · 2017Article
- Membrane Cholesterol Reduces Polymyxin B Nephrotoxicity in Renal Membrane Analogs.Biophysical journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Wide angle x-ray scattering (WAXS) from oriented lipid multilayers was used to study the effect of adding cholesterol (Chol) or 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) to gel-phase 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayers. Small quantities (X < 0.10 mole fraction) of both molecules disrupt the tight packing of tilted chains of pure gel-phase DPPC, forming a more disordered, untilted phase. The addition of larger quantities of DOPC causes the sample to phase-separate into a gel-phase, characterized by a narrow WAXS peak, and liquid disordered phase, characterized by wide, diffuse WAXS scattering. In contrast, two WAXS peaks indicative of two coexisting phases were not observed in Chol/DPPC mixtures (X(Chol) = 0.07 to 0.40). Instead, Chol caused a gradual increase in the width of the WAXS peak, consistent with a gradual change from a more gel-like to a more liquid-like state rather than passing through a region of two phase coexistence. Our WAXS data include a huge amount of information. A new method of analysis suggests that WAXS data may provide definitive results relating to the disagreements between previously published phase diagrams for Chol/DPPC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.