ArticleGenome research2009
Unusual composition of a yeast chromosome arm is associated with its delayed replication.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Absence of chromosome axis protein recruitment prevents meiotic recombination chromosome-wide in the budding yeastProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Intragenomic variation in non-adaptive nucleotide biases causes underestimation of selection on synonymous codon usage.PLoS genetics · 2022Article
- An Integrative View of the Role ofFoods (Basel, Switzerland) · 2021Review
- Dissection of quantitative trait loci in the Lachancea waltii yeast species highlights major hotspots.G3 (Bethesda, Md.) · 2021Article
- Pervasive Phenotypic Impact of a Large Nonrecombining Introgressed Region in Yeast.Molecular biology and evolution · 2020Article
- Unlocking a signal of introgression from codons in Lachancea kluyveri using a mutation-selection model.BMC evolutionary biology · 2020Article
- The evolution of the temporal program of genome replication.Nature communications · 2018Article
- Repeated evolution of self-compatibility for reproductive assurance.Nature communications · 2018Article
- Reconstruction of ancestral chromosome architecture and gene repertoire reveals principles of genome evolution in a model yeast genus.Genome research · 2016Article
- Whole-Genome Sequencing and Intraspecific Analysis of the Yeast Species Lachancea quebecensis.Genome biology and evolution · 2016Article
- A Comprehensive Characterization of Simple Sequence Repeats in the Sequenced Trichoderma Genomes Provides Valuable Resources for Marker Development.Frontiers in microbiology · 2016Article
- Evolution of intraspecific transcriptomic landscapes in yeasts.Nucleic acids research · 2015Article
- Article
- Population genomics reveals chromosome-scale heterogeneous evolution in a protoploid yeast.Molecular biology and evolution · 2015Article
- The spatiotemporal program of replication in the genome of Lachancea kluyveri.Genome biology and evolution · 2013Article
- Conservation of replication timing reveals global and local regulation of replication origin activity.Genome research · 2012Article
- Novel features of ARS selection in budding yeast Lachancea kluyveri.BMC genomics · 2011Article
- Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.G3 (Bethesda, Md.) · 2011Article
- Yeast evolutionary genomics.Nature reviews. Genetics · 2010Review
- A comprehensive genome-wide map of autonomously replicating sequences in a naive genome.PLoS genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 11.3-Mb genome of the yeast Lachancea (Saccharomyces) kluyveri displays an intriguing compositional heterogeneity: a region of approximately 1 Mb, covering almost the whole left arm of chromosome C (C-left), has an average GC content of 52.9%, which is significantly higher than the 40.4% global GC content of the rest of the genome. This region contains the MAT locus, which remains normal in composition. The excess of GC base pairs affects both coding and noncoding sequences, and thus is not due to selective pressure acting on protein sequences. It leads to a strong codon usage bias and alters the amino acid composition of the 457 proteins encoded on C-left that do not show obvious bias for functional categories, or the presence of paralogs or orthologs of essential genes of Saccharomyces cerevisiae. They share significant synteny conservation with other species of the Saccharomycetaceae, and phylogenetic analysis indicates that C-left originates from a Lachancea species. In contrast, there is a complete absence of transposable elements in C-left, whereas 18 elements per megabase are distributed across the rest of the genome. Comparative hybridization of synchronized cells using high-density genome arrays reveals that C-left is replicated later during S phase than the rest of the genome. Two possible primary causes of this major compositional heterogeneity are discussed: an ancient hybridization of two related species with very distinct GC composition, or an intrinsic mechanism, possibly associated with the loss of the silent cassettes from C-left that progressively increased the GC content and generated the delayed replication of this chromosomal arm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.