ArticleMolecular biology and evolution2009
Sequence-based analysis of protein energy landscapes reveals nonuniform thermal adaptation within the proteome.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Molecular Adaptations of Thermophilic Proteins-From Mechanistic Understanding to Machine Learning Approaches.ChemistryOpen · 2026Review
- Ensemble molecular mimicry correlates with antibody cross-reactivity in proteome-wide studies.Frontiers in immunology · 2026Article
- Heat tolerance, oxidative stress response tuning and robust gene activation in early-stageProceedings. Biological sciences · 2024Article
- Microbe-aided thermophilic composting accelerates manure fermentation.Frontiers in microbiology · 2024Article
- A Thermodynamic Atlas of Proteomes Reveals Energetic Innovation across the Tree of Life.Molecular biology and evolution · 2022Article
- The quiet evolutionary response to cellular challenges.American journal of botany · 2022Article
- Conserved allosteric ensembles in disordered proteins using TROSY/anti-TROSY RBiophysical journal · 2021Article
- Convergent Evolution and Structural Adaptation to the Deep Ocean in the Protein-Folding Chaperonin CCTα.Genome biology and evolution · 2020Article
- Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- High-throughput quantification of protein structural change reveals potential mechanisms of temperature adaptation in Mytilus mussels.BMC evolutionary biology · 2020Article
- Integrating GWAS and Transcriptomics to Identify the Molecular Underpinnings of Thermal Stress Responses inFrontiers in genetics · 2020Article
- Thermophiles; or, the Modern Prometheus: The Importance of Extreme Microorganisms for Understanding and Applying Extracellular Electron Transfer.Frontiers in microbiology · 2019Article
- Sequence-Based Analysis of Thermal Adaptation and Protein Energy Landscapes in an Invasive Blue Mussel (Mytilus galloprovincialis).Genome biology and evolution · 2017Article
- A functional approach to uncover the low-temperature adaptation strategies of the archaeon Methanosarcina barkeri.Applied and environmental microbiology · 2013Article
- Evolutionary force in confamiliar marine vertebrates of different temperature realms: adaptive trends in zoarcid fish transcriptomes.BMC genomics · 2012Article
- PROTS: a fragment based protein thermo-stability potential.Proteins · 2012Article
- The role of protein conformational fluctuations in allostery, function, and evolution.Biophysical chemistry · 2011Review
- How do thermophilic proteins and proteomes withstand high temperature?Biophysical journal · 2011Article
- Back to the sea twice: identifying candidate plant genes for molecular evolution to marine life.BMC evolutionary biology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Thermal adaptation of individual proteins is often achieved through modulating protein stability, with proteins that are adapted to extreme cold environments having increased conformational flexibility when brought to mesophilic conditions. Conversely, proteins adapted to higher temperatures appear less dynamic and are found to be much more stable against thermal denaturation than their mesophilic counterparts. According to the current paradigm, the adaptation of an organism for survival at higher or lower temperatures is facilitated by the adaptation of the component proteins. We note, however, that these observations have been carried out on relatively few proteins. The extent to which the conformational stabilities of all members of the proteome have been modulated for thermal adaptation remains unclear, with no direct experimental strategies to address this issue. Adapted extremophilies are likely to use a multitude of molecular and biophysical strategies for survival and, therefore, evolution of specific biophysical properties of proteins for optimal function may not be necessary for all proteins in the proteome. Using a sequence-based predictor of protein stability, eScape, an in silico examination of several extremophilic proteomes shows a correlation between the collective stability of the proteins and the thermal range of survival for the organism as expected. Unexpectedly, however, the analysis shows that protein thermostability is modified to different extents across the proteome and depends on the functional role for which the protein is involved. Identification of these differences provides unique opportunities to study interdependence within the proteome as well as the role that the proteome plays in the process of evolutionary thermal adaptation.
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Registered trials
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